2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling
  3. Polo-like Kinase (PLK) PIN1 STAT
  4. Poloxipan

Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research.

For research use only. We do not sell to patients.

Poloxipan

Poloxipan Chemical Structure

CAS No. : 1239513-63-3

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Poloxipan Related Antibodies

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STAT3 STAT5 STAT6 STAT1

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Description

Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research[1].
Molecular Weight

380.22

Formula

C14H10BrN3O3S
CAS No.
SMILES

O=C1N2C(S/C1=C\C3=C(C=CC(Br)=C3)OC)=NC(C(C)=N2)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Poloxipan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poloxipan1239513-63-3Polo-like Kinase (PLK)PIN1STATpeptidylprolyl cis/trans isomerase, NIMA-interacting 1Inhibitorinhibitorinhibit

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