Ceftaroline  (Synonyms: T-91825; PPI-0903M)

T-91825 (PPI-0903M), an N-phosphono-type cephalosporin, is the active form of TAK-599. T-91825 is active against both gram-positive and gram-negative bacteria^[1][2].

PPI-0903M is very active against S. aureus (MIC₅₀=0.25 μg/mL), including methicillin-resistant (MRSA) strains (MIC₅₀=1 μg/mL)^[1].
PPI-0903M is active against hetero-vancomycin-intermediate S. aureus (100 strains), with MIC₅₀s ranging from 0.25 to 4 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AK-599 (20 mg/kg; s.c. three times a day for 2 days) decreases the bacterial cell counts in lungs more than 99.9% in a mouse pneumonia model caused by MRSA^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

604.70

C₂₂H₂₀N₈O₅S₄

189345-04-8

Solid

White to yellow

C[N+]1=CC=C(C2=CSC(SC(CS[C@]3([H])[C@@H]4NC(/C(C5=NSC(N)=N5)=N\OCC)=O)=C(C([O-])=O)N3C4=O)=N2)C=C1

Shipping with dry ice.

-80°C, stored under nitrogen

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.

• [1]. Sader HS, et, al. Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains. Antimicrob Agents Chemother. 2005 Aug;49(8):3501-12.  [Content Brief]

  [2]. Iizawa Y, et, al. In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599. J Infect Chemother. 2004 Jun;10(3):146-56.  [Content Brief]