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  4. Tobevibart

Tobevibart  (Synonyms: VIR-3434)

Cat. No.: HY-P990015 Purity: 95.00%
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Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda1, Isotype Control (HY-P99992).

For research use only. We do not sell to patients.

CAS No. : 2645440-65-7

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Based on 1 publication(s) in Google Scholar

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Description

Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda1, Isotype Control (HY-P99992)[1].

In Vitro

Tobevibart efficiently neutralizes HDV genotypes 1-3 and 5-8 in a dose-dependent manner with EC50 values ranging from 1.14 to 4.56 ng/mL. Tobevibart has pan-genotypic neutralization activity against different HBV/HDV combinations in vitro[1].
Tobevibart reduces infectious HDV levels in HBV/HDV co-infected primary human hepatocytes (PHH) in an additive manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tobevibart Related Antibodies
Molecular Weight

143234.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tobevibart]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tobevibart2645440-65-7VIR-3434VIR3434VIR 3434HBVHepatitis B virusInhibitorinhibitorinhibit

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