2. Anti-infection
  3. Bacterial
  4. JNJ-6640

JNJ-6640 is an inhibitor targeting mycobacterial PurF (the first enzyme in the de novo purine biosynthesis pathway) with potent anti-tuberculosis activity. JNJ-6640 exhibits bactericidal activity against Mycobacterium tuberculosis in vitro, with an MIC90 of 8.6 nM. JNJ-6640 disrupts de novo purine biosynthesis, inhibits M. tuberculosis DNA replication in vivo. JNJ-6640 exhibits anti-tuberculosis efficacy in acutely infected mice. JNJ-6640 can be used for the study of tuberculosis.

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JNJ-6640

JNJ-6640 Chemical Structure

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JNJ-6640 Related Antibodies

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Description

JNJ-6640 is an inhibitor targeting mycobacterial PurF (the first enzyme in the de novo purine biosynthesis pathway) with potent anti-tuberculosis activity. JNJ-6640 exhibits bactericidal activity against Mycobacterium tuberculosis in vitro, with an MIC90 of 8.6 nM. JNJ-6640 disrupts de novo purine biosynthesis, inhibits M. tuberculosis DNA replication in vivo. JNJ-6640 exhibits anti-tuberculosis efficacy in acutely infected mice. JNJ-6640 can be used for the study of tuberculosis[1].

In Vitro

JNJ-6640 exhibits potent in vitro inhibitory and bactericidal activity against Mycobacterium tuberculosis H37Rv strain, with a minimum inhibitory concentration (MIC90) of 8.6 nM and a minimum bactericidal concentration (MBC99.9) of 140 nM; in cholesterol medium, (MIC90) is 29.1 nM; for intracellular M. tuberculosis in THP-1 macrophages IC50 is 26.1 nM[1].
JNJ-6640 (100 nM, 4 h) significantly reduces the incorporation ratio of 15N into adenine and adenosine monophosphate (AMP) in M. tuberculosis[1].
JNJ-6640 (1 nM) inhibits M. tuberculosis PurF enzyme[1].
JNJ-6640 (0.6 μM, 6-10 h) arrests the growth of M. tuberculosis expressing TdTomato[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-6640 Related Antibodies
In Vivo

JNJ-6640 (1500 mg/kg, s.c. injection of long-acting injectable, once weekly for 2-8 weeks) exhibits anti-tuberculosis efficacy in acutely infected female Balb/cBy mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mycobacterium tuberculosis H37Rv (200 CFU) was intranasally inoculated into 6-8-week-old female Balb/cBy mice to construct an acute tuberculosis infection model[1]
Dosage: 1500 mg/kg
Administration: s.c. injection of LAI, once weekly for 2, 8 weeks
Result: Reduced lung bacterial load.
Showed no significant changes in body weight and no obvious clinical signs of toxicity.
Reduced the phosphorylation of molecules related to M. tuberculosis DNA replication in mice.
Molecular Weight

340.35

Formula

C17H17FN6O
SMILES

CC1=NNC(OC2=C(F)C=NC(N3C[C@H](CC3)C4=CC=NC=C4)=N2)=C1
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Purity & Documentation
References
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JNJ-6640 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-6640JNJ6640JNJ 6640BacterialMycobacterium tuberculosistuberculosisPurFInhibitorinhibitorinhibit

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