Pam2Cys  (Synonyms: Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis(palmitoyloxy)propyl]cysteine)

Pam2Cys (Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis(palmitoyloxy)propyl]cysteine) is a selective agonist of dendritic cell TLR2, targeting the lipid portion of dendritic cells. Pam2Cys works by targeting and activating dendritic cells, thereby inducing strong immune responses, such as the production of specific antibodies. Pam2Cys enhances immunogenicity without the need for exogenous adjuvants. Pam2Cys can be applied to vaccine research, especially the development of lipopeptide vaccines against influenza A virus and other viruses to induce protective immune responses^[1][2][3].

672.05

C₃₈H₇₃NO₆S

656831-18-4

O=C([C@@H](N)CSCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pejoski D, et al. A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody. Immunol Cell Biol. 2010 Jul;88(5):605-11.  [Content Brief]

  [2]. Franzoni G, et al. Targeting Toll-Like Receptor 2: Polarization of Porcine Macrophages by a Mycoplasma-Derived Pam2cys Lipopeptide. Vaccines (Basel). 2021 Jun 23;9(7):692.  [Content Brief]

  [3]. Tan AC, et al. Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice. Mol Pharm. 2012 Sep 4;9(9):2710-8.  [Content Brief]