2. Stem Cell/Wnt
  3. Wnt
  4. FIDAS-3

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities.

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FIDAS-3 Chemical Structure

FIDAS-3 Chemical Structure

CAS No. : 1266684-01-8

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Based on 1 publication(s) in Google Scholar

FIDAS-3 Related Antibodies

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Description

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

IC50 & Target

IC50: 4.9 μM (Methionine S-adenosyltransferase 2A (MAT2A))[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
32.1 μM
Compound: 1a
Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay
Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay
[PMID: 24950374]
LS174T IC50
26.9 nM
Compound: 1a
Antiproliferative activity against human LS 174T cells by cell viability analyzer
Antiproliferative activity against human LS 174T cells by cell viability analyzer
[PMID: 24950374]
LS174T IC50
59 nM
Compound: 1
Antiproliferative activity against human LS 174T cells after 4 days by Vi-Cell cell viability analyzer
Antiproliferative activity against human LS 174T cells after 4 days by Vi-Cell cell viability analyzer
[PMID: 24930834]
In Vitro

FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells[1].
FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1[1].
FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FIDAS-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: LS174T colorectal cancer (CRC) cells
Concentration: 3 μM
Incubation Time: 7 days
Result: Significantly inhibited the proliferation of LS174T cells.
In Vivo

FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; daily; for one months
Result: Significantly inhibited the growth of xenograft tumors.
Molecular Weight

259.29

Formula

C16H15F2N
CAS No.
Appearance

Solid

Color

Off-white to light green

SMILES

CN(C)C1=CC=C(/C=C/C2=C(F)C=CC=C2F)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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FIDAS-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FIDAS-31266684-01-8FIDAS3FIDAS 3WntMAT2Aanti-cancerS-adenosylmethionineSAMSAHc-MycCyclinD1anti-proliferationβ-cateninInhibitorinhibitorinhibit

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