2. Anti-infection Apoptosis
  3. Influenza Virus HSV HCV Apoptosis Caspase
  4. Moroxydine

Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].

For research use only. We do not sell to patients.

Moroxydine Chemical Structure

Moroxydine Chemical Structure

CAS No. : 3731-59-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Moroxydine:

Other Forms of Moroxydine:

Moroxydine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Moroxydine

View All HSV Isoform Specific Products:

View All Isoforms
HSV-1 HSV-2 HSV

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].

In Vitro

Moroxydine hydrochloride (HY-B0420A) used in papers

Moroxydine (1-100 μg/mL, 24-96 h) shows protective effects against grass carp reovirus (GCRV) in Ctenopharyngodon idella kidney (CIK) cells (TC50 = 1246.0 μg/mL, SC = 218.5 μg/mL) and grass carp ovary (GCO) cells (TC50 = 117.2 μg/mL, SC = 140.9 μg/mL)[1][2].

Moroxydine (1-100 μg/mL, 24-96 h) shows protective effects against giant salamander iridovirus (GSIV) in epithelioma papulosum cyprinid (EPC) cells, with a TC50 of 1486.3 μg/mL and a safe concentration (SC) of 209.7 μg/mL[2].

Moroxydine (40 μg/mL, 48-96 h) blocks the virus-induced CPE and cell death within 96 h and maintained the normal structure and nucleocapsids[1].

Moroxydine (40 μg/mL, 48-96 h) significantly decreases the apoptosis in CIK cells (GCRV), GCO cells (GCRV) and EPC cells (GSIV)[1][2].

Moroxydine (12-48 h) significantly inhibits the caspase 3 activity, Bax expression and down-regulates Bcl-2 at 48 h in CIK cells[1].

Moroxydine (20 μg/mL, 12-72 h) shows time-dependent suppression of viral gene expression in CIK cells(GCRV), GCO cells (GCRV) and EPC cells (GSIV)[1][2].

Moroxydine (20 μg/mL, 72 h) arrests cell cycle in the period of G1/S and G2/M of CIK cells[3].

Moroxydine (3-7 days) inhibits the GCRV-induced upregulation of immune genes (IL-1β, IFN-I, TNF-α) in the kidney, liver, muscle and gill[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Moroxydine Related Antibodies

Cell Viability Assay[1]

Cell Line: GCRV infected CIK cells
Concentration: 1, 2.5, 6.3, 15.9, 39.8, 100 μg/mL
Incubation Time: 24, 48, 72, 96 h
Result: Presented a better protective-efficiency than Ribavirin(HY-B0434).
Showed no significant difference when expose GCRV-infected CIK cells in 39.8 μg/mL compared with virus-free group at 96 h.

Apoptosis Analysis[1]

Cell Line: GCRV infected CIK cells
Concentration: 40 μg/mL
Incubation Time: 48 h
Result: Exhibited a positive inhibition in the GCRV infected cells compared with negative control.

Cell Cycle Analysis[3]

Cell Line: GCRV infected CIK cells
Concentration: 20 μg/mL
Incubation Time: 72 h
Result: Arrested cell cycle in the period of G1/S and G2/M of CIK cells

Real Time qPCR[1][3]

Cell Line: GCRV infected CIK cells
Concentration: 20 μg/mL
Incubation Time: 12, 24, 48, 72 h
Result: Suppressed viral genes (vp1, vp2, vp3 and vp4) at 12 h following a slow decrease from 12 h to 72 h post medication.
Inhibited the IL-1β expression.
Molecular Weight

171.20

Formula

C6H13N5O
CAS No.
SMILES

N=C(NC(N1CCOCC1)=N)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Moroxydine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moroxydine3731-59-7ABOBInfluenza VirusHSVHCVApoptosisCaspaseHerpes simplex virusHepatitis C virusCIK cellsGCO cellsEPC cellsGCRVGSIVapoptosisinfluenza virusherpes simplexvaricella zostermeaslesmumps diseasehepatitis C virusInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Moroxydine
Cat. No.:
HY-W016937
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.