2. Cytoskeleton
  3. Gap Junction Protein
  4. Gap19

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.

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Custom Peptide Synthesis

Gap19

Gap19 Chemical Structure

CAS No. : 1507930-57-5

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Based on 5 publication(s) in Google Scholar

Other Forms of Gap19:

Gap19 Related Antibodies

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Description

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial[1][2].

IC50 & Target

Cx43 Hemichannel[1]
In Vitro

Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake[1].
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells[2].
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes[2].
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gap19 Related Antibodies
In Vivo

Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice[2]
Dosage: 25 mg/kg
Administration: IV; 10 min before ligation
Result: Significantly reduced the infarct size by approximately one-fifth.
Molecular Weight

1161.44

Formula

C55H96N14O13
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

KQIEIKKFK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (86.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8610 mL 4.3050 mL 8.6100 mL
5 mM 0.1722 mL 0.8610 mL 1.7220 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.25%

SDS (252 KB)

COA (256 KB) RP-HPLC (112 KB) MS (221 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8610 mL 4.3050 mL 8.6100 mL 21.5250 mL
5 mM 0.1722 mL 0.8610 mL 1.7220 mL 4.3050 mL
10 mM 0.0861 mL 0.4305 mL 0.8610 mL 2.1525 mL
15 mM 0.0574 mL 0.2870 mL 0.5740 mL 1.4350 mL
20 mM 0.0431 mL 0.2153 mL 0.4305 mL 1.0763 mL
25 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.8610 mL
30 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7175 mL
40 mM 0.0215 mL 0.1076 mL 0.2153 mL 0.5381 mL
50 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.4305 mL
60 mM 0.0144 mL 0.0718 mL 0.1435 mL 0.3588 mL
80 mM 0.0108 mL 0.0538 mL 0.1076 mL 0.2691 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gap19 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gap191507930-57-5Gap 19Gap-19Gap Junction ProteinCx43connexinhemichannelC-terminusCTcytoplasmicloopCLGJchannelsCx40/pannexin-1myocardialInhibitorinhibitorinhibit

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