2. Apoptosis Epigenetics Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Apoptosis Bcl-2 Family Caspase MDM-2/p53 PARP Amylases
  4. Stigmast-5-en-3-ol

Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity.

For research use only. We do not sell to patients.

Stigmast-5-en-3-ol

Stigmast-5-en-3-ol Chemical Structure

CAS No. : 5779-62-4

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Stigmast-5-en-3-ol Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity[1][2][3].

IC50 & Target[1]

Caspase-9

 

Bax

 

Bcl-xL

 

In Vitro

Stigmast-5-en-3-ol (Compound DGEH21-3-2) (12.5-50 μg/mL, 24 h) shows cytotoxic effects against HL-60 and MCF-7 cells, with IC50 s of 37.82 and 45.17 μg/mL respectively[1].
Stigmast-5-en-3-ol (12.5-50 μg/mL, 24 h) induces apoptosis, increases DNA damage, increases production of Bax, Caspase-9, p53 and PARP cleavage, and decreased Bcl-xl levels in HL-60 and MCF-7 cells[1].
Stigmast-5-en-3-ol (Compound 24R) (2-10 μg/mL, 30 min) exhibits potent inhibitory activity against glucoamylase and α-amylase with IC50 s of 5.8 and 7.198 µg/mL respectively, shows high radical activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stigmast-5-en-3-ol Related Antibodies

Apoptosis[1]

Cell Line: HL-60 and MCF-7 cells
Concentration: 12.5, 25, 50 μg/mL
Incubation Time: 24 h
Result: Increased the number of apoptotic bodies and dose-dependently increased the sub-G1 apoptotic cell population, resulting in a sub-G1 apoptotic cell population of 66.30% in HL-60 cells and 60.05% in MCF-7 cells at 50 μg/ml.
Increased production of Bax, Caspase-9, and PARP cleavage, and decreased Bcl-xl levels.
Dose-dependent increased p53 expression in MCF-7 cells.
Molecular Weight

414.71

Formula

C29H50O
CAS No.
SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC(CC4)O)=CC3)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Stigmast-5-en-3-ol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stigmast-5-en-3-ol5779-62-4ApoptosisBcl-2 FamilyCaspaseMDM-2/p53PARPAmylasespoly ADP ribose polymeraseHL-60 cellsMCF-7 cellsleukemiabreast cancertype 2 diabetesobesityInhibitorinhibitorinhibit

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