ODN 1826 sodium  (Synonyms: CpG 1826 sodium)

ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 sodium induces NO and iNOS production and enhances Apoptosis. ODN 1826 sodium enhances immune surveillance. ODN 1826 sodium increases aortic atherosclerotic plaque size. ODN 1826 sodium has antitumor activity against lung cancer, glioma and melanoma^{[1][2][3][4][5][6]}.

ODN 1826 (1 μg/mL; 24 h) sodium induces nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production in RAW 264.7 mouse macrophages^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CpG-1826 (100 μg/tumor; intratumoral injection; every 3 days for up to 4 times) sodium delays the growth of subcutaneously implanted GL261 gliomas in C57BL/6NTac mice, inducing increased infiltration of macrophages and B cells into tumors, with significant growth delay in ~50% of mice^[4].
ODN 1826 (18 nM; s.c.; 3 times a week for 7 weeks) sodium increases aortic atherosclerotic plaque size in a chronic vascular injury mouse model^[5].
ODN 1826 (0.05 mg; i.p.; 1, 3, 5, 8, 11, 13 days) sodium has a strong anti-tumor growth effect in a Lewis lung cancer mouse tumor model^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6804.00

Solid

White to off-white

[ODN 1826 (sodium)]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Hou Y, et al. Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells. J Agric Food Chem. 2019 Jul 24;67(29):8227-8234.  [Content Brief]

  [2]. Qi XF, et al. CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways. Mol Immunol. 2013 Jul;54(3-4):327-37.  [Content Brief]

  [3]. Utaisincharoen P, et al. CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7). Clin Exp Immunol. 2002 Jun;128(3):467-73.  [Content Brief]

  [4]. Jordan M, et al. CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model. Cancer Lett. 2016 Apr 1;373(1):88-96.  [Content Brief]

  [5]. Krogmann AO, et al. Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice. PLoS One. 2016 Jan 11;11(1):e0146326.  [Content Brief]

  [6]. Yuan S, et al. CpG oligodeoxynucleotide 1826 enhances the Lewis lung cancer response to radiotherapy in murine tumor. Cancer Biother Radiopharm. 2011 Apr;26(2):203-8.  [Content Brief]