2. Adjuvant
  3. Targeted Pattern Recognition Receptor-Type Adjuvants

Targeted Pattern Recognition Receptor-Type Adjuvants

Bacteria, fungi, viruses, and certain components of plants can activate the innate immune system by targeting pattern recognition receptors, thereby becoming potential vaccine adjuvants. Toll-like receptors are transmembrane signaling molecules expressed on the surface of immune cells. The ligands that bind to them must be highly specific, and these ligands are pathogen-associated molecular patterns with distinct evolutionary characteristics.

 

Targeted Pattern Recognition Receptor-Type Adjuvants (58):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-107202
    Polyinosinic-polycytidylic acid 24939-03-5 99.40%
    Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
    Polyinosinic-polycytidylic acid
  • HY-10964
    Vadimezan 117570-53-3 99.93%
    Vadimezan (DMXAA), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.
    Vadimezan
  • HY-100564
    2',3'-cGAMP 1441190-66-4 99.95%
    2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.
    2',3'-cGAMP
  • HY-12885A
    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt 1638750-95-4 99.91%
    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).
    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt
  • HY-100564A
    2',3'-cGAMP sodium 2734858-36-5 99.89%
    2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.
    2',3'-cGAMP sodium
  • HY-N15893
    α-Galactosyl FP20 sodium 3056013-94-3
    α-Galactosyl FP20 sodium, a TLR-4 agonist, is a vaccine adjuvant.
    α-Galactosyl FP20 sodium
  • HY-N16009
    α-Rhamnosyl FP20 sodium 3056013-95-4
    α-Rhamnosyl FP20 sodium, a TLR-4 agonist, is a vaccine adjuvant.
    α-Rhamnosyl FP20 sodium
  • HY-N16013
    FP-18 disodium 2936622-27-2
    FP-18 disodium, a TLR-4 agonist, is a vaccine adjuvant.
    FP-18 disodium
  • HY-112921B
    diABZI STING agonist-1 trihydrochloride 2138299-34-8 99.92%
    diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1 trihydrochloride
  • HY-150218
    Agatolimod sodium 541547-35-7 99.13%
    Agatolimod sodium (ODN 2006) is a class B CpG ODN and is a TLR9 agonist. Agatolimod sodium can be used as vaccine adjuvant. Agatolimod sodium can be used for the research of cancer. Sequence: 5’-TCGTCGTTTTGTCGTTTTGTCGTT-3’.
    Agatolimod sodium
  • HY-112921A
    diABZI STING agonist-1 2138299-33-7 99.86%
    diABZI STING agonist-1 is a tautomerism of diABZI STING agonist-1 tautomerism (HY-112921). diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    diABZI STING agonist-1
  • HY-146245C
    ODN 1826 sodium 99.51%
    ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 sodium induces NO and iNOS production and enhances Apoptosis. ODN 1826 sodium enhances immune surveillance. ODN 1826 sodium increases aortic atherosclerotic plaque size. ODN 1826 sodium has antitumor activity against lung cancer, glioma and melanoma.
    ODN 1826 sodium
  • HY-12512
    cGAMP 849214-04-6 99.22%
    cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
    cGAMP
  • HY-12885B
    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt 1638750-96-5 99.89%
    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • HY-146245
    ODN 1826 202668-42-6 99.69%
    ODN 1826 is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 induces NO and iNOS production and enhances Apoptosis. ODN 1826 enhances immune surveillance. ODN 1826 increases aortic atherosclerotic plaque size. ODN 1826 has antitumor activity against lung cancer, glioma and melanoma.
    ODN 1826
  • HY-12326A
    c-di-AMP disodium 2734909-87-4 99.14%
    c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
    c-di-AMP disodium
  • HY-146244
    Agatolimod 525625-52-9 98.49%
    Agatolimod (ODN 2006), a class B ODN (oligodeoxynucleotide), is a TLR9 agonist. Agatolimod is also an optimal CpG sequence for humans. Agatolimod stimulates very strong production of NO2 and IL-6 in HD11 cells. Agatolimod can be used for breast cancer research. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'.
    Agatolimod
  • HY-150741C
    ODN 2216 sodium 98.57%
    ODN 2216 sodium is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 sodium induces high amounts of IFN-α and IFN-β. ODN 2216 sodium induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 sodium stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 sodium can activate NK cells and promote IFN-γ production of TCR-triggered CD4+ T cells.
    ODN 2216 sodium
  • HY-150724C
    ODN 1018 sodium
    ODN 1018 sodium, an oligodeoxynucleotide, is a TLR-9 agonist. ODN 1018 sodium is also a synthetic immunostimulatory sequence that can be used as vaccine adjuvant. Sequence: 5′-TGACTGTGAACGTTCGAGATGA-3′.
    ODN 1018 sodium
  • HY-110385
    cGAMP disodium 2407516-83-8 98.47%
    cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
    cGAMP disodium