2. Adjuvant
  3. Targeted Pattern Recognition Receptor-Type Adjuvants

Targeted Pattern Recognition Receptor-Type Adjuvants

Bacteria, fungi, viruses, and certain components of plants can activate the innate immune system by targeting pattern recognition receptors, thereby becoming potential vaccine adjuvants. Toll-like receptors are transmembrane signaling molecules expressed on the surface of immune cells. The ligands that bind to them must be highly specific, and these ligands are pathogen-associated molecular patterns with distinct evolutionary characteristics.

 

Targeted Pattern Recognition Receptor-Type Adjuvants (14):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-146244
    Agatolimod 525625-52-9 98.49%
    Agatolimod (ODN 2006), a class B ODN (oligodeoxynucleotide), is a TLR9 agonist. Agatolimod is also an optimal CpG sequence for humans. Agatolimod stimulates very strong production of NO2 and IL-6 in HD11 cells. Agatolimod can be used for breast cancer research. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'.
    Agatolimod
  • HY-150724C
    ODN 1018 sodium
    ODN 1018 sodium, an oligodeoxynucleotide, is a TLR-9 agonist. ODN 1018 sodium is also a synthetic immunostimulatory sequence that can be used as vaccine adjuvant. Sequence: 5′-TGACTGTGAACGTTCGAGATGA-3′.
    ODN 1018 sodium
  • HY-12885
    2’3’-c-di-AM(PS)2 (Rp,Rp) 1638241-89-0 99.85%
    2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
    2’3’-c-di-AM(PS)2 (Rp,Rp)
  • HY-160225
    ISD sodium 98.02%
    ISD (interferon stimulatory DNA) sodium is a non-CpG oligomer from the Listeria monocytogenes genome. When transfected into cells, ISD sodium strongly enhances the expression of IFN-β. This ISD-induced response is mediated by the STING-TBK1-IRF3 signaling axis.
    ISD sodium
  • HY-12326B
    c-di-AMP diammonium 99.36%
    c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
    c-di-AMP diammonium
  • HY-N16301
    Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium
    Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium, a lipid, is an adjuvant. Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium has immunostimulatory properties.
    Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium
  • HY-N16009
    α-Rhamnosyl FP20 sodium 3056013-95-4
    α-Rhamnosyl FP20 sodium, a TLR-4 agonist, is a vaccine adjuvant.
    α-Rhamnosyl FP20 sodium
  • HY-N16013
    FP-18 disodium 2936622-27-2
    FP-18 disodium, a TLR-4 agonist, is a vaccine adjuvant.
    FP-18 disodium
  • HY-139586
    Ulevostinag 2082743-96-0 98.05%
    Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research.
    Ulevostinag
  • HY-N15893
    α-Galactosyl FP20 sodium 3056013-94-3
    α-Galactosyl FP20 sodium, a TLR-4 agonist, is a vaccine adjuvant.
    α-Galactosyl FP20 sodium
  • HY-N16020
    α-Glucosyl FP20 sodium 3056013-97-6
    α-Glucosyl FP20 sodium, a TLR-4 agonist, is a vaccine adjuvant.
    α-Glucosyl FP20 sodium
  • HY-N16021
    4A-MPLA ammonium 2260669-09-6
    4A-MPLA (ammonium) can be used as an adjuvant in vaccine. 4A-MPLA (ammonium) induces tissue-specific immune response. 4A-MPLA (ammonium) can enhance resistance against endotoxin induced effects in host and decrease cytokine production during infection.
    4A-MPLA ammonium
  • HY-160222
    HSV-60mer sodium
    HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome. Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR)-, DNA-dependent activator of IRFs (DAI)-, and RNA polymerase III (Pol III)-independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3)-dependent manner.
    HSV-60mer sodium
  • HY-160224
    dsVACV-70mer sodium
    dsVACV-70mer (sodium) is a 70 bp double-stranded oligonucleotide containing viral DNA motifs derived from vaccinia virus DNA. dsVACV-70mer (sodium) has potently induces IFN-β via a STING-dependent manner.
    dsVACV-70mer sodium