2. Apoptosis Immunology/Inflammation
  3. IFNAR TNF Receptor
  4. ODN 1585 sodium

ODN 1585 sodium is a potent inducer of IFN and TNFα production. ODN 1585 sodium is a potent stimulator of NK (natural killer) function. ODN 1585 sodium increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 sodium induces regression of established melanomas in mice. ODN 1585 sodium can confer complete protection against malaria in mice. ODN 1585 sodium can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 sodium can be used as a vaccine adjuvant.

For research use only. We do not sell to patients.

DNA, d(G-sp-G-G-G-T-C-A-A-C-G-T-T-G-A-G-G-sp-G-sp-G-sp-G-sp-G), sodium salt

ODN 1585 sodium Chemical Structure

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Based on 1 publication(s) in Google Scholar

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ODN 1585 sodium Related Antibodies

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TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

ODN 1585 sodium is a potent inducer of IFN and TNFα production. ODN 1585 sodium is a potent stimulator of NK (natural killer) function. ODN 1585 sodium increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 sodium induces regression of established melanomas in mice. ODN 1585 sodium can confer complete protection against malaria in mice. ODN 1585 sodium can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 sodium can be used as a vaccine adjuvant[1][2][3].

In Vitro

ODN 1585 (3 μg/mL, 48 h) sodium induces PBMC producing IFN-α in the nanogram range[3].
ODN 1585 sodium increases the percentage of CD69+ (early marker of activation) NK cells within 24 h (26%)[3].
CpG ODN (0.6μg/mL, 18 h) sodium stimulates NK cell-mediated lysis of K562 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ODN 1585 sodium Related Antibodies
In Vivo

ODN 1585 (50-500 μg, Injection into the tibialis anterior muscle, single) sodium protects 20 to 90% of mice from sporozoite infection[1].
ODN 1585 (100 μg/dose, IP, twice weekly) sodium is determined to be optimal for the induction of antitumor responses in several systems involving comparisons of 30, 100, and 300 μg/injection[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c ByJ mice (4- to 8-week-old, female, 6-18 mice in each group)[1]
Dosage: 50, 100, 200, or 500 μg (in 50 μL of saline)
Administration: Injection into the tibialis anterior muscle, single (at 7, 2, or 1 day(s) prior to sporozoite infection, on the day of infection, and/or at 1 day postinfection)
Result: Protected 20 to 90% of mice from infection when the ODN 1585 was administered around the time of sporozoite challenge with doses of 50 to 500 μg. The highest level of protection (90%) resulted from administration of 200 μg of CpG ODN 1585 the day before challenge or 100 μg of CpG ODN 1585 on the day before and the day of challenge.
Molecular Weight

6889.80

Appearance

Solid

Color

White to off-white

SMILES

[DNA, d(G-sp-G-G-G-T-C-A-A-C-G-T-T-G-A-G-G-sp-G-sp-G-sp-G-sp-G), sodium salt]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 93.90%

SDS (251 KB)

COA (239 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References
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ODN 1585 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 1585ODN1585ODN-1585IFNARTNF ReceptorInterferon-α/β receptorInterferon-alpha/beta receptor Tumor Necrosis Factor ReceptorTNFRNK cellsnatural killerCD8+ T cellsCpG ODNmalariaantimalaria effectacute myelogenous leukemiaAMLInhibitorinhibitorinhibit

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