2. PROTAC Protein Tyrosine Kinase/RTK Neuronal Signaling MAPK/ERK Pathway Stem Cell/Wnt
  3. PROTACs Trk Receptor ERK
  4. JWJ-01-378

JWJ-01-378 is a selective TRK PROTAC degrader. JWJ-01-378 efficiently degrades WT TRK and TPM3-TRKA fusion proteins and inhibits downstream pERK signaling, while showing limited efficacy against TRK inhibitor resistant mutants and ALK fusions. JWJ-01-378 potently suppresses cancer cell proliferation.Pink: TRK ligand (HY-160520); Blue: CRBN ligase ligand (HY-103596); Black: linker

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JWJ-01-378

JWJ-01-378 Chemical Structure

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JWJ-01-378 Related Antibodies

Top Publications Citing Use of Products

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TrkA TrkB TrkC Trk

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ERK ERK1 ERK2 ERK5 ERK8

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Description

JWJ-01-378 is a selective TRK PROTAC degrader. JWJ-01-378 efficiently degrades WT TRK and TPM3-TRKA fusion proteins and inhibits downstream pERK signaling, while showing limited efficacy against TRK inhibitor resistant mutants and ALK fusions. JWJ-01-378 potently suppresses cancer cell proliferation[1].Pink: TRK ligand (HY-160520); Blue: CRBN ligase ligand (HY-103596); Black: linker

Molecular Weight

1045.14

Formula

C55H62F2N10O9
SMILES

O=C(NCCCCCCCCNC(CN1CCN(CC1)C2=CC(NC3CCOCC3)=C(C=C2)C(NC4=NNC5=C4C=C(C=C5)CC6=CC(F)=CC(F)=C6)=O)=O)COC7=C8C(N(C(C8=CC=C7)=O)C9CCC(NC9=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JWJ-01-378 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JWJ-01-378PROTACsTrk ReceptorERKTropomyosin related kinase receptor Extracellular signal regulated kinasesPROTACDegradationTRKTPM3-TRKAHEL cellsKM12 cellsInhibitorinhibitorinhibit

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