2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. WHN-11

WHN-11 is an amino-Artemisinin (HY-B0094) derivative with anti-cancer activity against various cancer cell lines. WHN-11 deprives the cell of ATP, activates autophagy, and causes subsequent cell death by apoptosis. WHN-11 alters cellular protein homeostasis pathways to induce mitochondrial fission and dysfunction. WHN-11's anti-cancer activity is independent of substantive ROS production. WHN-11 can be used for the study of triple-negative breast cancer (TNBC).

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WHN-11

WHN-11 Chemical Structure

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WHN-11 Related Antibodies

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Description

WHN-11 is an amino-Artemisinin (HY-B0094) derivative with anti-cancer activity against various cancer cell lines. WHN-11 deprives the cell of ATP, activates autophagy, and causes subsequent cell death by apoptosis. WHN-11 alters cellular protein homeostasis pathways to induce mitochondrial fission and dysfunction. WHN-11's anti-cancer activity is independent of substantive ROS production. WHN-11 can be used for the study of triple-negative breast cancer (TNBC)[1].

In Vitro

WHN-11 exhibits significant cytotoxicity against HCC1937 (IC50 = 0.74 μM), HCC70 (0.19 μM) and MDA-MB-231 TNBC cell lines (0.5 μM), HeLa cervical carcinoma (0.84 μM), U87 glioblastoma (6.57 μM), 501mel melanoma (0.2 μM) and HCT116 colon cancer cell lines (0.44 μM)[1].
WHN-11 inhibits tumoursphere formation in the HCC1937 TNBC cell line[1].
WHN-11 (5-80 μM, 9 days) significantly decreases colony formation of HCC1937 cells in a dose-dependent manner[1].
WHN-11 (1-50 μM, 24 h) promotes the cleavage of caspase-3 in a dose-dependent fashion rather than RARP-1[1].
WHN-11 does not alter ROS and NQO1 mRNA levels in HCC1937 cells[1].
WHN-11 perturbs protein homeostasis, including ubiquitination and proteasomal degradation in HCC1937 cells[1].
WHN-11 (0.1-40 μM, 1-16 h) activates apoptotic and autophagic signaling pathways in HCC1937 cells[1].
WHN-11 (1-50 μM) induces an indication of mitochondrial stress and dysfunction of HCC1937 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WHN-11 Related Antibodies

Western Blot Analysis[1]

Cell Line: HCC1937 cells
Concentration: 0.1, 10 and 50 μM
Incubation Time: 1, 4 and 16 h
Result: Induced both autophagy (as indicated by LC3B-I lipidation) and apoptosis (as indicated by caspase-3 cleavage) only after a prolonged exposure of 16 h.
Molecular Weight

539.59

Formula

C27H36F3N3O5
SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@H]1N5CCN(CC5)C(NC6=CC=C(C=C6)C(F)(F)F)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WHN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WHN-11WHN11WHN 11ApoptosisAutophagyAmino-artemisininTriple-negative breast cancerReactive oxygen speciesMitochondrial fissionInhibitorinhibitorinhibit

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