N'-Isonicotinoylisonicotinohydrazide  (Synonyms: 1,2-Diisonicotinoylhydrazine)

N'-Isonicotinoylisonicotinohydrazide (Compound 7, 1,2-Diisonicotinoylhydrazine) is a competitive inhibitor (IC₅₀=5-30 μM) of bacterial heme oxygenase (HO). N'-Isonicotinoylisonicotinohydrazide inhibits iron release and bacterial iron acquisition. N'-Isonicotinoylisonicotinohydrazide exhibits selective activity against HO enzymes from Pseudomonas aeruginosa and Neisseria meningitidis. N'-Isonicotinoylisonicotinohydrazide is promising for research of multidrug-resistant Gram-negative bacterial infections^[1][2].

242.23

C₁₂H₁₀N₄O₂

4329-75-3

O=C(C1=CC=NC=C1)NNC(C2=CC=NC=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Furci LM, et al. Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. J Med Chem. 2007 Aug 9;50(16):3804-13.  [Content Brief]

  [2]. Panda SS, et al. Synthesis, computational studies, antimycobacterial and antibacterial properties of pyrazinoic acid-isoniazid hybrid conjugates. RSC Adv. 2019 Jul 1;9(35):20450-20462.  [Content Brief]