2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. AWL-II-38.3

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf.

For research use only. We do not sell to patients.

AWL-II-38.3 Chemical Structure

AWL-II-38.3 Chemical Structure

CAS No. : 1135205-94-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

AWL-II-38.3 Related Antibodies

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Description

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].

IC50 & Target

Ephrin-A receptor (EphA3) kinase[1][2]
In Vitro

AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AWL-II-38.3 Related Antibodies
Molecular Weight

469.42

Formula

C23H18F3N5O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC=NO1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C=NC(C)=C4)=C3)=O)=CC=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (213.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1303 mL 10.6514 mL 21.3029 mL
5 mM 0.4261 mL 2.1303 mL 4.2606 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1303 mL 10.6514 mL 21.3029 mL 53.2572 mL
5 mM 0.4261 mL 2.1303 mL 4.2606 mL 10.6514 mL
10 mM 0.2130 mL 1.0651 mL 2.1303 mL 5.3257 mL
15 mM 0.1420 mL 0.7101 mL 1.4202 mL 3.5505 mL
20 mM 0.1065 mL 0.5326 mL 1.0651 mL 2.6629 mL
25 mM 0.0852 mL 0.4261 mL 0.8521 mL 2.1303 mL
30 mM 0.0710 mL 0.3550 mL 0.7101 mL 1.7752 mL
40 mM 0.0533 mL 0.2663 mL 0.5326 mL 1.3314 mL
50 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0651 mL
60 mM 0.0355 mL 0.1775 mL 0.3550 mL 0.8876 mL
80 mM 0.0266 mL 0.1331 mL 0.2663 mL 0.6657 mL
100 mM 0.0213 mL 0.1065 mL 0.2130 mL 0.5326 mL
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AWL-II-38.3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AWL-II-38.31135205-94-5Ephrin ReceptorEphA3LIMK2LIMK1ATPInhibitorinhibitorinhibit

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