2. Anti-infection Stem Cell/Wnt
  3. Antibiotic Wnt β-catenin Bacterial
  4. Dinactin

Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 μM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain.

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Dinactin

Dinactin Chemical Structure

CAS No. : 20261-85-2

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Based on 1 publication(s) in Google Scholar

Dinactin Related Antibodies

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Description

Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 μM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain[1].

In Vitro

Dinactin (compound 1) shows antibacterial activity with MIC values of 1, 0.039, 0.019, 0.078, 0.078, 0.156, 0.156, 0.156, 0.156 μg/ml for M.tuberculosis(ATCC 25177), S. epidermidis(ATCC 12228), M. luteus(ATCC10240), S. aureus(ATCC 35923), E. faecalis(ATCC 51299), B. subtilis(ATCC 11774), E. coli(ATCC 10536), P. aeruginosa(ATCC 10145), K. pneumonia(ATCC BAA-2146) strain, respectively[1].
Dinactin (0-100 μM) shows antitumor activity with IC50 values of 1.3, 1.1, 1.3, 1.5, 9.7, 80 μM for A549, HCT-116, T47D, MCF7, HepG2, HEK-293 cells, respectively[1].
Dinactin (0.5, 1, 2 μM; 24 h) induces morphological changes in a concentration dependent manner in HCT-116 cells[1].
inactin (0.5, 1, 2 μM; 24 h) effectively inhabits cell migration and invasion characteristics in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dinactin Related Antibodies
Molecular Weight

764.98

Formula

C42H68O12
CAS No.
SMILES

CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3CC)=O)C)CC5)C)=O)C)([H])CC4
Initial Source

Streptomyces aureus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dinactin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dinactin20261-85-2AntibioticWntβ-cateninBacterialBeta cateninantibiotic ionophoreWnt/β-catenin signaling pathwaycancerHCT-116apoptosis-independent mannerneuropathic painInhibitorinhibitorinhibit

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