N-Deschlorobenzoyl indomethacin-d₃ 

N-Deschlorobenzoyl indomethacin-d₃ is the deuterium labeled N-Deschlorobenzoyl indomethacin (HY-W008567). N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC₅₀ =100 μM, AKR1C3 IC₅₀ >100 μM), exhibiting no selectivity^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

222.26

C₁₂H₁₀D₃NO₃

3029090-15-8

2882-15-7

CC(NC1=C2C=C(OC([2H])([2H])[2H])C=C1)=C2CC(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liedtke AJ, et al. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J Med Chem. 2013 Mar 28;56(6):2429-46.  [Content Brief]