Anti-Rat IL-4 Antibody (OX-81) 

Anti-Rat IL-4 Antibody (OX-81) is an antibody inhibitor against rat IL-4. Anti-Rat IL-4 Antibody (OX-81) can specifically block the anti-inflammatory effect of IL-4. Anti-Rat IL-4 Antibody (OX-81) can be used for research on inflammation conditions such as experimental allergic encephalomyelitis (EAE)^[1][2].

Mouse IgG1 kappa

Mouse IgG1 kappa, Isotype Control

IL-4

Anti-Rat IL-4 Antibody (OX-81) (0.3 μg/mL) can significantly reverse the inhibitory effect of exogenous IL-4 (such as restoring NO and TNF-α to Lipopolysaccharides (LPS) (HY-D1056) stimulated levels) in glial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Rat IL-4 Antibody (OX-81) (7 mg/kg, i.p., once daily, for 14 days) delays the onset time of the experimental allergic encephalomyelitis (EAE) in female Lewis (RT-1^l) rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

16189  [NCBI]

P07750

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Rat IL-4 Antibody (OX-81)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tran GT, et al. Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on T(h)1 cells that is augmented by IL-4. Int Immunol. 2001 Sep;13(9):1109-20.  [Content Brief]

  [2]. Ledeboer A, et al. Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells. Glia. 2000 Apr;30(2):134-42.  [Content Brief]