2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. APN-PEG5-VC-PAB-MMAE

APN-PEG5-VC-PAB-MMAE is a drug-linker conjugate part of INA03 (a transferrin-competitive antibody-drug conjugate against CD71).

For research use only. We do not sell to patients.

APN-PEG5-VC-PAB-MMAE

APN-PEG5-VC-PAB-MMAE Chemical Structure

CAS No. : 2252392-31-5

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Based on 1 publication(s) in Google Scholar

APN-PEG5-VC-PAB-MMAE Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

APN-PEG5-VC-PAB-MMAE is a drug-linker conjugate part of INA03 (a transferrin-competitive antibody-drug conjugate against CD71)[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

APN-PEG5-VC-PAB-MMAE Related Antibodies
Molecular Weight

1577.90

Formula

C81H120N14O18
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCC(N=N4)=CN4C5=CC=C(C#CC#N)C=C5)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)=O)=O)=O)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (31.69 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6338 mL 3.1688 mL 6.3375 mL
5 mM 0.1268 mL 0.6338 mL 1.2675 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6338 mL 3.1688 mL 6.3375 mL 15.8438 mL
5 mM 0.1268 mL 0.6338 mL 1.2675 mL 3.1688 mL
10 mM 0.0634 mL 0.3169 mL 0.6338 mL 1.5844 mL
15 mM 0.0423 mL 0.2113 mL 0.4225 mL 1.0563 mL
20 mM 0.0317 mL 0.1584 mL 0.3169 mL 0.7922 mL
25 mM 0.0254 mL 0.1268 mL 0.2535 mL 0.6338 mL
30 mM 0.0211 mL 0.1056 mL 0.2113 mL 0.5281 mL
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APN-PEG5-VC-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APN-PEG5-VC-PAB-MMAE2252392-31-5Drug-Linker Conjugates for ADCMMAE-LinkerInhibitorinhibitorinhibit

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APN-PEG5-VC-PAB-MMAE
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