2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Loperamide

Loperamide (ADL 2-1294) is a selective μ opioid receptor agonist with Kis of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide can be used as an antidiarrheal agent.

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Loperamide

Loperamide Chemical Structure

CAS No. : 53179-11-6

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Based on 8 publication(s) in Google Scholar

Other Forms of Loperamide:

Loperamide Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

Loperamide (ADL 2-1294) is a selective μ opioid receptor agonist with Kis of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide can be used as an antidiarrheal agent[1].

IC50 & Target

Ki: 3 nM (μ opioid receptor), 48 nM (δ opioid receptor), 1156 nM (κ opioid receptor)[1]
Clinical Trial
Molecular Weight

477.04

Formula

C29H33ClN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1=CC=CC=C1)(CCN2CCC(C3=CC=C(C=C3)Cl)(CC2)O)C4=CC=CC=C4)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (209.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0963 mL 10.4813 mL 20.9626 mL
5 mM 0.4193 mL 2.0963 mL 4.1925 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

SDS (392 KB)

COA (250 KB) HNMR (296 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0963 mL 10.4813 mL 20.9626 mL 52.4065 mL
5 mM 0.4193 mL 2.0963 mL 4.1925 mL 10.4813 mL
10 mM 0.2096 mL 1.0481 mL 2.0963 mL 5.2407 mL
15 mM 0.1398 mL 0.6988 mL 1.3975 mL 3.4938 mL
20 mM 0.1048 mL 0.5241 mL 1.0481 mL 2.6203 mL
25 mM 0.0839 mL 0.4193 mL 0.8385 mL 2.0963 mL
30 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.7469 mL
40 mM 0.0524 mL 0.2620 mL 0.5241 mL 1.3102 mL
50 mM 0.0419 mL 0.2096 mL 0.4193 mL 1.0481 mL
60 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.8734 mL
80 mM 0.0262 mL 0.1310 mL 0.2620 mL 0.6551 mL
100 mM 0.0210 mL 0.1048 mL 0.2096 mL 0.5241 mL
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Loperamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Loperamide53179-11-6ADL 2-1294Opioid ReceptorantihyperalgesicantidiarrhealdiarrheaInhibitorinhibitorinhibit

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