2. Anti-infection
  3. Bacterial
  4. Cyclo(L-Pro-L-Val)

Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclo(L-Pro-L-Val) Chemical Structure

Cyclo(L-Pro-L-Val) Chemical Structure

CAS No. : 2854-40-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclo(L-Pro-L-Val):

Cyclo(L-Pro-L-Val) Related Antibodies

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  • Purity & Documentation

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Description

Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases[1][2].

Cellular Effect
Cell Line Type Value Description References
HCT-116 EC50
> 100 μM
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
[PMID: 36518704]
HCT-116 EC50
> 100 μM
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells overexpressing human MDR1 incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells overexpressing human MDR1 incubated for 48 hrs by MTT assay
[PMID: 36518704]
HCT-116 EC50
> 100 μM
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells overexpressing human BCRP incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells overexpressing human BCRP incubated for 48 hrs by MTT assay
[PMID: 36518704]
HEK293 EC50
> 100 μM
Compound: DKPPVal
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
[PMID: 36518704]
In Vitro

Cyclo(L-Pro-L-Val) (MIC=19.6 mg/mL) shows toxic activity comparable to that of 25 mg/mL Chloramphenicol (HY-B0239) in the antibacterial experiment against Rhodococcus fascians LMG 3605 and could reduce the viability of Rhodococcus fascians LMG 3605 cells[1]Cyclo(L-Pro-L-Val) (25-100 μM; treated for 1 hour and then co-incubated with LPS for 24 hours) significantly inhibits the production of NO in RAW 264.7 macrophages stimulated by LPS in the anti-inflammatory experiment of RAW 264.7 macrophages, and the inhibitory effect is equivalent to that of L-NMMA (HY-18732)[2]Cyclo(L-Pro-L-Val) (50-100 μM；24 h) inhibits the phosphorylation of IKKα, IKKβ, and NF-κB, as well as the activation of iNOS and COX-2 in RAW 264.7 macrophages induced by LPS in a concentration-dependent manner[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclo(L-Pro-L-Val) Related Antibodies

Western Blot Analysis[2]

Cell Line: RAW 264.7 macrophages
Concentration: 50 μM, 100 μM
Incubation Time: Treated for 1 hour and then co-incubated with 1 μg/mL LPS for 24 h
Result: Significantly inhibited expression of IKKα/β, I-κBα, and NF-κB in a concentration dependent manner.
Molecular Weight

196.25

Formula

C10H16N2O2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Pro-Val)
Sequence Shortening

Cyclo(PV)
Structure Classification
Initial Source

Streptomyces strain ML 1532
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (509.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0955 mL 25.4777 mL 50.9554 mL
5 mM 1.0191 mL 5.0955 mL 10.1911 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.0955 mL 25.4777 mL 50.9554 mL 127.3885 mL
5 mM 1.0191 mL 5.0955 mL 10.1911 mL 25.4777 mL
10 mM 0.5096 mL 2.5478 mL 5.0955 mL 12.7389 mL
15 mM 0.3397 mL 1.6985 mL 3.3970 mL 8.4926 mL
20 mM 0.2548 mL 1.2739 mL 2.5478 mL 6.3694 mL
25 mM 0.2038 mL 1.0191 mL 2.0382 mL 5.0955 mL
30 mM 0.1699 mL 0.8493 mL 1.6985 mL 4.2463 mL
40 mM 0.1274 mL 0.6369 mL 1.2739 mL 3.1847 mL
50 mM 0.1019 mL 0.5096 mL 1.0191 mL 2.5478 mL
60 mM 0.0849 mL 0.4246 mL 0.8493 mL 2.1231 mL
80 mM 0.0637 mL 0.3185 mL 0.6369 mL 1.5924 mL
100 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2739 mL
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Cyclo(L-Pro-L-Val) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(L-Pro-L-Val)2854-40-2BacterialInhibitorinhibitorinhibit

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