2. Apoptosis
  3. Transferrin Receptor
  4. Anti-Mouse CD71/TfR1 Antibody (8D3)

Anti-Mouse CD71/TfR1 Antibody (8D3) 

Cat. No.: HY-P990129 Purity: 95.00%
COA
SDS
Technical Support

Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection.

For research use only. We do not sell to patients.

Anti-Mouse CD71/TfR1 Antibody (8D3) Chemical Structure

Anti-Mouse CD71/TfR1 Antibody (8D3) Chemical Structure

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Anti-Mouse CD71/TfR1 Antibody (8D3) Featured Recommendations:

Anti-Mouse CD71/TfR1 Antibody (8D3) Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection[1][2].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
IC50 & Target

CD71/TfR1
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD71/TfR1 Antibody (8D3) Related Antibodies
In Vivo

Anti-Mouse CD71/TfR1 Antibody (8D3) (150 μg, i.p., on days 5 and 6 after birth) enhances neonatal mice defence against infection[1].
Anti-Mouse CD71/TfR1 Antibody (8D3) (150 μg, i.p., on days 9 after birth) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-day-old neonatal mice [1]
Dosage: 150 μg
Administration: Intraperitoneally injection at days 5 and 6 after birth
Result: Significant reduced the number of recoverable L. monocytogenes bacteria.
Significantly produced more TNF-α and upregulated expression of the co-stimulatorymolecules CD40, CD80 and CD86.
Restored neonatal resistance to E. coli infection.
Animal Model: Neonatal mice [2]
Dosage: 150 μg
Administration: Intraperitoneally injection at day 9 after birth
Result: Reduced approximately 60% of CD71+ erythroid cells in the spleen of mice.
Had no significant effects on the percentage of Tregs.
Significantly up-regulated VISTA expression in both the percentages and MFI of VISTA expression.
Upregulated Id1 and Id2 genes and produced TGF-β.
Gene ID

64678  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD71/TfR1 Antibody (8D3)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Mouse CD71/TfR1 Antibody (8D3) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD71/TfR1 Antibody (8D3)Transferrin ReceptorTfRCD71TfR1TregsInfectionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-Mouse CD71/TfR1 Antibody (8D3)
Cat. No.:
HY-P990129
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.