2. Anti-infection Immunology/Inflammation NF-κB
  3. Bacterial IFNAR Nuclear Factor of activated T Cells (NFAT) NF-κB
  4. Centaurein

Centaurein, a flavonoid, is an IFN-γ promoter enhancer. Centaurein up-regulates the activity of NFAT and NF-κB enhancers. Centaurein increases the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaureidin completely relaxes the contractions in intact rat aortic rings. Centaurein effectively protects mice against Listeria infection[1][2][3][4].

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Centaurein Chemical Structure

Centaurein Chemical Structure

CAS No. : 35595-03-0

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Centaurein Related Antibodies

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Description

Centaurein, a flavonoid, is an IFN-γ promoter enhancer. Centaurein up-regulates the activity of NFAT and NF-κB enhancers. Centaurein increases the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaureidin completely relaxes the contractions in intact rat aortic rings. Centaurein effectively protects mice against Listeria infection[1][2][3][4].

In Vitro

Centaurein (5-100 μg/mL, 24-72 h) can stimulate IFN-γ transcription in a T cell line (Jurkat cells) and splenocytes and up-regulates the activity of NFAT and NF-κB enhancers[1][2][3].

Centaurein (100 μg/mL, 24 h) up-regulates the transcription of T-bet and IFN-γ but not GATA-3 and IL-4 in T cells[2].

Centaurein (6 h) pretreatment reduces Listeria infection in macrophages from 46% to 15%, an effect partially reversed (34% infection) by IFN-γ-neutralizing antibody[2].

Centaureidin (10-100 μM) completely relaxes the contractions induced by Norepinephrine (NA) (HY-13715) (IC50 = 16.7 μM) or by a high K concentration (IC50 =16.1 μM) in intact rat aortic rings concentration-dependently[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Centaurein Related Antibodies

Real Time qPCR[2]

Cell Line: T cells
Concentration: 100 μg/mL
Incubation Time: 24 h
Result: Increased the expression of T-bet by 5-fold.
Enhanced the transcription of IFN-γ but not IL-4 or GATA-3.
In Vivo

Centaurein (20 μg/mouse, i.p., single dose) augments the serum IFN-γ level in mice, which peaked 24 h post-injection[2].

Centaurein (20 μg/mouse, i.p., single dose) protects against and treats Listeriainfection in mice via up-regulation of IFN-γ and macrophage activation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks C57BL/6J mice and IFN-γ−/− C57BL/6J mice[2]
Dosage: 20 μg/mouse
Administration: i.p. for single dose
Result: Protected mice against Listeria infection in a dose-dependent fashion.
Did not protect IFN-γ-knockout mice against Listeria infection, but Ampicillin (HY-B0522) at 1000 μg/mL could protect against Listeria infection.
Rescued 30% of the mice infected with a lethal dose of Listeria (2 × 10 6 CFU).
Rescued 70% of the mice that received the lethal dose of Listeria in combination with antibiotics (5 μg/mouse, 2 times/day for 3 days)
Molecular Weight

522.46

Formula

C24H26O13
CAS No.
SMILES

O=C1C2=C(O)C(OC)=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2OC(C4=CC(O)=C(C=C4)OC)=C1OC
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

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References
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Centaurein Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Centaurein35595-03-0BacterialIFNARNuclear Factor of activated T Cells (NFAT)NF-κBInterferon-α/β receptorInterferon-alpha/beta receptor Nuclear factor-κBNuclear factor-kappaBBidens pilosaListeriaIFN-γNFATT cellsNK cellsInhibitorinhibitorinhibit

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