2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. Topoisomerase ADC Payload
  4. Topi MF-6

Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 has superior cytotoxicity against gastrointestinal cancer cells. Topi MF-6 can be used as an ADC payload.

For research use only. We do not sell to patients.

Topi MF-6 Chemical Structure

Topi MF-6 Chemical Structure

CAS No. : 2944016-96-8

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Topi MF-6 Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

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  • Purity & Documentation

  • References

  • Customer Review

Description

Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 has superior cytotoxicity against gastrointestinal cancer cells. Topi MF-6 can be used as an ADC payload[1].

IC50 & Target[1]

Top1

 

Molecular Weight

439.41

Formula

C23H19F2N3O4
CAS No.
SMILES

CC[C@@](C1=C(CO2)C(N3CC4=C5C6=C(CCC5(F)F)C(N)=CC=C6N=C4C3=C1)=O)(O)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topi MF-6 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topi MF-62944016-96-8Topi MF6Topi MF 6TopoisomeraseADC PayloadADC CytotoxinInhibitorDNA Topoisomerase 1Top1Gastrointestinal cancerADC payloadinhibitorinhibit

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