2. Epigenetics Anti-infection
  3. Small Interfering RNA (siRNA) HBV
  4. Elebsiran sodium

Elebsiran sodium  (Synonyms: VIR-2218 sodium)

Cat. No.: HY-147266 Purity: 95.83%
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Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections.

For research use only. We do not sell to patients.

Gene Regulation Tool

RNA, (Gm-sp-Um-sp-Gm-Um-(2′-deoxy-2′-fluoro)G-Cm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Um-Cm-Gm-Cm-Um-Um-Cm-Am-Cm-Am), 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)G-sp-Um-Gm-Am-(3′→3′)-[9-de-β-D-ribofuranosyl-9-[(2S)-2,3-dihydroxypropyl]]A-(2′→5′)-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-Am-Am-Gm-Um-(2′-deoxy-2′-fluoro)G-Cm-(2′-deoxy-2′-fluoro)A-Cm-Am-Cm-sp-Um-sp-Um) (1:1), sodium salt

Elebsiran sodium Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Elebsiran sodium Related Antibodies

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Description

Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections[1][2][3].

In Vitro

Elebsiran (0.1 pM-100 nM) sodium effectively reduces HBsAg and the infectivity of HDV, and when combined with Tobevibart (HY-P990015) for treatment, it shows an additive effect[1].
Elebsiran sodium exhibits comparable antiviral activity to ALN-HBV in HepG2.2.15 cells but its cytotoxicity is significantly reduced[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Elebsiran sodium Related Antibodies
Parmacokinetics[2]
Species Dose Route Indicator value
Monkey 10 mg/kg s.c. Tmax 24 h
Rat 10 mg/kg s.c. Tmax 7 h
Monkey 10 mg/kg s.c. Cmax 135000 ng/g
Rat 10 mg/kg s.c. Cmax 97000 ng/g
Monkey 10 mg/kg s.c. AUClast 37200000 h·ng/g
Rat 10 mg/kg s.c. AUClast 6610000 h·ng/g
Monkey 10 mg/kg s.c. T1/2 160 h
Rat 10 mg/kg s.c. T1/2 93.1 h
In Vivo

Elebsiran (9 mg/kg, s.c., single dose) sodium possess antiviral activity against HBV and HDV in mice[1].
Elebsiran (12-100 mg/kg, s.c., 5 doses on Days 0, 21, 28, 35, and 42) sodium does not cause a significant increase in ALT in all dosage groups and demonstrates high liver safety in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HBV/HDV-coinfected liver-chimeric model established in liver-chimeric mice[1]
Dosage: 9 mg/kg alone or with 15 mg/kg muHBC34 (the murinized version of Tobevibart)
Administration: Subcutaneous injection (s.c.), single dose
Result: Significant decreased of 0.6 log for HBsAg, 0.5 log for HBV DNA and 0.7 log for HDV RNA compared to the vehicle control on day 14 post-treatment.
Led to the strongest reductions in HBsAg, HBV DNA and HDV RNA levels relative to the vehicle group with muHBC34.
Animal Model: Chimeric mouse model established male PXB mice at 12 to 18 weeks[3]
Dosage: 12 mg/kg, 36 mg/kg, and 100 mg/kg
Administration: Subcutaneous injection (s.c.), on Days 0, 21, 28, 35, and 42
Result: Observed a clear dose-dependent increase in hALT1 levels, whereas no relationship between hALT1 and dose level.
Clinical Trial
Molecular Weight

15855.90

Formula

C485H658F9N158O294P39S6
Appearance

Solid

Color

White to off-white

SMILES

[Elebsiran sodium]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (6.31 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.0631 mL 0.3153 mL 0.6307 mL
5 mM 0.0126 mL 0.0631 mL 0.1261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 95.83%

SDS (252 KB)

COA (250 KB) LCMS (658 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.0631 mL 0.3153 mL 0.6307 mL 1.5767 mL
5 mM 0.0126 mL 0.0631 mL 0.1261 mL 0.3153 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Elebsiran sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ElebsiranVIR-2218VIR2218VIR 2218Small Interfering RNA (siRNA)HBVHepatitis B virussiRNAvirologyHBV surface antigenInhibitorinhibitorinhibit

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