2. Membrane Transporter/Ion Channel Neuronal Signaling NF-κB
  3. Calcium Channel NF-κB
  4. Manidipine dihydrochloride (Standard)

Manidipine dihydrochloride (Standard) 

Cat. No.: HY-17403R Purity: ≥98%
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Manidipine (dihydrochloride) (Standard) is the analytical standard of Manidipine (dihydrochloride). This product is intended for research and analytical applications. Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection.

For research use only. We do not sell to patients.

Manidipine dihydrochloride (Standard) Chemical Structure

Manidipine dihydrochloride (Standard) Chemical Structure

CAS No. : 89226-75-5

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Description

Manidipine (dihydrochloride) (Standard) is the analytical standard of Manidipine (dihydrochloride). This product is intended for research and analytical applications. Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection.

Molecular Weight

683.62

Formula

C35H40Cl2N4O6
CAS No.
SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3.[H]Cl.[H]Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Manidipine dihydrochloride (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Manidipine dihydrochloride (Standard)89226-75-5Calcium ChannelNF-κBCa2+ channelsCa channelsNuclear factor-κBNuclear factor-kappaBLipophilicvasoselectivecalcium channel antagonistantihypertensiveanti-inflammatoryflavivirusnegative-strand RNA virusescardiovascularmetabolic diseaseIFNAR2/2 miceBALB/c miceInhibitorinhibitorinhibit

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