2. Others Neuronal Signaling PI3K/Akt/mTOR NF-κB
  3. Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB
  4. Skimmianine (Standard)

Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca2+ signaling and protein kinase C signaling.

For research use only. We do not sell to patients.

Skimmianine (Standard) Chemical Structure

Skimmianine (Standard) Chemical Structure

CAS No. : 83-95-4

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Skimmianine (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Skimmianine (Standard)83-95-4Reference StandardsCholinesterase (ChE)PI3KAktNF-κBPhosphoinositide 3-kinasePKBProtein kinase BNuclear factor-κBNuclear factor-kappaBanalgesicantispasticsedativeantiplateletaggregationgenotoxicityInhibitorinhibitorinhibit

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