2. Immunology/Inflammation Apoptosis
  3. NO Synthase COX Caspase MDM-2/p53
  4. Neuroprotective agent 11

Neuroprotective agent 11 (Compound 1a) is an orally active polyphenol compound with significant protective effects against cerebral ischemia. The main activities of Neuroprotective agent 11 include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarction volume, and improving behavioral symptoms of cerebral ischemic mice. Neuroprotective agent 11 exerts its regulatory mechanism by downregulating the expression of inflammatory factors (iNOS、COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 can be used in the study of cerebral ischemia-related diseases (such as ischemic stroke).

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Neuroprotective agent 11 Chemical Structure

Neuroprotective agent 11 Chemical Structure

CAS No. : 3081915-81-0

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Neuroprotective agent 11 Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Neuroprotective agent 11 (Compound 1a) is an orally active polyphenol compound with significant protective effects against cerebral ischemia. The main activities of Neuroprotective agent 11 include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarction volume, and improving behavioral symptoms of cerebral ischemic mice. Neuroprotective agent 11 exerts its regulatory mechanism by downregulating the expression of inflammatory factors (iNOS、COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 can be used in the study of cerebral ischemia-related diseases (such as ischemic stroke)[1].

Molecular Weight

606.57

Formula

C32H30O12
CAS No.
SMILES

CCC1=C2C([C@@H](C3=C(O)C=C(O)C4=C3O[C@H](C5=CC=C(O)C(O)=C5)[C@@H](O)C4)[C@H](O)[C@@H](C6=CC=C(O)C(O)=C6)O2)=C(O)C=C1O
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Neuroprotective agent 11 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroprotective agent 113081915-81-0Neuroprotective agent11Neuroprotective agent-11NO SynthaseCOXCaspaseMDM-2/p53Nitric oxide synthasesNOSCyclooxygenaseHT22 cellsOGD/RC57 miceSD ratsInhibitorinhibitorinhibit

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