Dihydrostreptomycin  (Synonyms: DHSM)

Dihydrostreptomycin (DHSM) is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss^[1].

Dihydrostreptomycin blocks mechanoelectric transduction channels, induces increased intracellular calcium concentrations, and leads to the obstruction of auditory signal transmission^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydrostreptomycin (600 mg/kg, ip, once daily for 12 days) induces spiral ligament damage in mice, promotes the proliferation of spiral ligament cells in the mouse cochlea, and the expression of FGF receptors and connexin 43 in the spiral ligament^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

611.64

C₂₃H₄₅N₇O₁₂

128-46-1

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• [1]. Marcotti W, et al. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005 Sep 1;567(Pt 2):505-21.  [Content Brief]

  [2]. Yamashita H, et al., Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate. Acta Otolaryngol. 1999;119(3):322-5.  [Content Brief]