2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK
  3. Antibody-Drug Conjugates (ADCs) TAM Receptor
  4. Enapotamab vedotin

Enapotamab vedotin is an AXL-targeted antibody-drug conjugate (ADC) with inhibitory potential against high AXL expressing non-small cell lung cancer (NSCLC). Enapotamab vedotin also exhibits resistant to EGFR inhibitor such as Osimertinib (HY-15772).

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Enapotamab vedotin Chemical Structure

Enapotamab vedotin Chemical Structure

CAS No. : 1912424-97-5

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Enapotamab vedotin Related Antibodies

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Description

Enapotamab vedotin is an AXL-targeted antibody-drug conjugate (ADC) with inhibitory potential against high AXL expressing non-small cell lung cancer (NSCLC). Enapotamab vedotin also exhibits resistant to EGFR inhibitor such as Osimertinib (HY-15772)[1].

IC50 & Target

AXL[1]
In Vitro

Enapotamab vedotin (0-10 μg/mL, 5 days) exhibits cytotoxicity in cells with high AXL expression such as ER20 and H1975-OR2, and reduces the cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enapotamab vedotin Related Antibodies

Cell Viability Assay[1]

Cell Line: ER20, H1975-OR2
Concentration: 0-10 μg/mL
Incubation Time: 5 days
Result: Reduced the cell viability.
In Vivo

Enapotamab vedotin (2-4 mg/kg, iv, once weekly for 2 doses) exhibits antitumor efficacy against various non-small cell lung cancer (NSCLC) with high AXL expression such as LU0395, exhibits resistant to EGFR inhibitor in LU1868 or LU0858 xenograft mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LU0395 xenograft mouse models[1]
Dosage: 2-4 mg/kg
Administration: iv, once weekly for 2 doses
Result: Inhibited the tumor growth.
CAS No.
SMILES

[Enapotamab vedotin]
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Purity & Documentation
References
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Enapotamab vedotin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enapotamab vedotin1912424-97-5HuMax-AXL-ADCAntibody-Drug Conjugates (ADCs)TAM ReceptorAntibody-Drug ConjugatesTyro3AxlMerInhibitorinhibitorinhibit

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