2. Anti-infection
  3. Bacterial
  4. (R)-DS86760016

(R)-DS86760016 is the R-enantiomer of DS86760016 (HY-124679). DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

For research use only. We do not sell to patients.

(R)-DS86760016 Chemical Structure

(R)-DS86760016 Chemical Structure

CAS No. : 3075275-82-7

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(R)-DS86760016 Related Antibodies

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Description

(R)-DS86760016 is the R-enantiomer of DS86760016 (HY-124679). DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa[1].

Molecular Weight

243.45

Formula

C9H11BClNO4
CAS No.
SMILES

OB(O1)C(C(OCO2)=C2C=C3)=C3[C@@H]1CN.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (410.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1076 mL 20.5381 mL 41.0762 mL
5 mM 0.8215 mL 4.1076 mL 8.2152 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.1076 mL 20.5381 mL 41.0762 mL 102.6905 mL
5 mM 0.8215 mL 4.1076 mL 8.2152 mL 20.5381 mL
10 mM 0.4108 mL 2.0538 mL 4.1076 mL 10.2690 mL
15 mM 0.2738 mL 1.3692 mL 2.7384 mL 6.8460 mL
20 mM 0.2054 mL 1.0269 mL 2.0538 mL 5.1345 mL
25 mM 0.1643 mL 0.8215 mL 1.6430 mL 4.1076 mL
30 mM 0.1369 mL 0.6846 mL 1.3692 mL 3.4230 mL
40 mM 0.1027 mL 0.5135 mL 1.0269 mL 2.5673 mL
50 mM 0.0822 mL 0.4108 mL 0.8215 mL 2.0538 mL
60 mM 0.0685 mL 0.3423 mL 0.6846 mL 1.7115 mL
80 mM 0.0513 mL 0.2567 mL 0.5135 mL 1.2836 mL
100 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0269 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(R)-DS86760016 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-DS867600163075275-82-7Bacterialleucyl-tRNA synthetaseLeuRSMDR Gram-negative bacteriaEscherichia coliKlebsiella pneumoniaePseudomonas aeruginosaInhibitorinhibitorinhibit

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