2. Others MAPK/ERK Pathway Autophagy
  3. Reference Standards p38 MAPK Autophagy
  4. Pamapimod (Standard)

Pamapimod (Standard)  (Synonyms: Ro4402257 (Standard); R1503 (Standard))

Cat. No.: HY-10405R
Handling Instructions Technical Support

Pamapimod (Standard) is the analytical standard of Pamapimod. This product is intended for research and analytical applications. Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.

For research use only. We do not sell to patients.

Pamapimod (Standard)

Pamapimod (Standard) Chemical Structure

CAS No. : 449811-01-2

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1 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
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25 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
50 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
100 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
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Information
Molecular Weight

406.38

Formula

C19H20F2N4O4
CAS No.
SMILES

O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC(CCO)CCO)N=C3N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Pamapimod (Standard) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pamapimod (Standard)449811-01-2Ro4402257 (Standard)R1503 (Standard)Reference Standardsp38 MAPKAutophagyp38αp38βanti-inflammationRATNF-αIL-6LPSJNKIL-1βInhibitorinhibitorinhibit

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