Hedychenone

Name: Hedychenone
Brand: MedChemExpress
SKU: HY-N4062
Rating: 4.5 (1 reviews)

Cat. No.: HY-N4062 Purity: 99.62%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Hedychenone (compound 3) is a labdane diterpene. Hedychenone can be isolated from the rhizomes of Hedychium yunnanense. Hedychenone against HeLa cell with IC₅₀ value of 9.76 μg/ml.

For research use only. We do not sell to patients.

Hedychenone Chemical Structure

CAS No. : 56324-54-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Hedychenone (compound 3) is a labdane diterpene. Hedychenone can be isolated from the rhizomes of Hedychium yunnanense. Hedychenone against HeLa cell with IC₅₀ value of 9.76 μg/ml.

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	21.13 μg/mL Compound: Hedychenone	Cytotoxicity against human A375 cells after 24 hrs Cytotoxicity against human A375 cells after 24 hrs	[PMID: 20303755]
A549	IC₅₀	33.12 μg/mL Compound: Hedychenone	Cytotoxicity against human A549 cells after 24 hrs Cytotoxicity against human A549 cells after 24 hrs	[PMID: 20303755]
A549	GI₅₀	7.4 μM Compound: 7	Growth inhibition of human A549 cells by Sulforhodamine B assay Growth inhibition of human A549 cells by Sulforhodamine B assay	[PMID: 21106458]
CHO	IC₅₀	8.2 μg/mL Compound: Hedychenone	Cytotoxicity against CHO cells after 24 hrs Cytotoxicity against CHO cells after 24 hrs	[PMID: 20303755]
HeLa	GI₅₀	63.2 μM Compound: 7	Growth inhibition of human HeLa cells by Sulforhodamine B assay Growth inhibition of human HeLa cells by Sulforhodamine B assay	[PMID: 21106458]
HL-60	IC₅₀	17.68 μg/mL Compound: Hedychenone	Cytotoxicity against human HL60 cells after 24 hrs Cytotoxicity against human HL60 cells after 24 hrs	[PMID: 20303755]
MCF7	GI₅₀	14.9 μM Compound: 7	Growth inhibition of human MCF7 cells by Sulforhodamine B assay Growth inhibition of human MCF7 cells by Sulforhodamine B assay	[PMID: 21106458]
MCF7	IC₅₀	19.41 μg/mL Compound: Hedychenone	Cytotoxicity against human MCF7 cells after 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs	[PMID: 20303755]
SK-N-SH	GI₅₀	11.6 μM Compound: 7	Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay	[PMID: 21106458]

Molecular Weight

298.42

Formula

C₂₀H₂₆O₂

CAS No.

56324-54-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](C(C=C([C@@H]2/C=C/C3=COC=C3)C)=O)([H])C(C)(CCC1)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (167.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3510 mL	16.7549 mL	33.5098 mL
5 mM	0.6702 mL	3.3510 mL	6.7020 mL
10 mM	0.3351 mL	1.6755 mL	3.3510 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (4.19 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.62%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (253 KB) HNMR (304 KB) LCMS (346 KB)

Handling Instructions (2659 KB)

References

[1]. Yu-Peng Li, et al. New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production. Natural Product Research. 2016.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3510 mL	16.7549 mL	33.5098 mL	83.7745 mL
	5 mM	0.6702 mL	3.3510 mL	6.7020 mL	16.7549 mL
	10 mM	0.3351 mL	1.6755 mL	3.3510 mL	8.3775 mL
	15 mM	0.2234 mL	1.1170 mL	2.2340 mL	5.5850 mL
	20 mM	0.1675 mL	0.8377 mL	1.6755 mL	4.1887 mL
	25 mM	0.1340 mL	0.6702 mL	1.3404 mL	3.3510 mL
	30 mM	0.1117 mL	0.5585 mL	1.1170 mL	2.7925 mL
	40 mM	0.0838 mL	0.4189 mL	0.8377 mL	2.0944 mL
	50 mM	0.0670 mL	0.3351 mL	0.6702 mL	1.6755 mL
	60 mM	0.0558 mL	0.2792 mL	0.5585 mL	1.3962 mL
	80 mM	0.0419 mL	0.2094 mL	0.4189 mL	1.0472 mL
	100 mM	0.0335 mL	0.1675 mL	0.3351 mL	0.8377 mL

Hedychenone Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hedychenone56324-54-0OthersNatural Products，DiterpeneInhibitorinhibitorinhibit

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Hedychenone

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Molarity Calculator

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Complete Stock Solution Preparation Table

Hedychenone Related Classifications

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