2. Apoptosis Immunology/Inflammation
  3. Pyroptosis
  4. Azalamellarin N

Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. Inhibitory potency against different pyroptosis inducers: Nigericin (HY-127019) > R837 (HY-B0180).

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Azalamellarin N

Azalamellarin N Chemical Structure

CAS No. : 1809535-57-6

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Based on 2 publication(s) in Google Scholar

Azalamellarin N Related Antibodies

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Description

Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. Inhibitory potency against different pyroptosis inducers: Nigericin (HY-127019) > R837 (HY-B0180)[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.0155 μM
Compound: 5
Cytotoxicity against human A549 cells harboring wild type EGFR assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells harboring wild type EGFR assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33556869]
NCI-H1975 IC50
0.0019 μM
Compound: 5
Cytotoxicity against human NCI-H1975 cells harboring T790M/L858R mutant assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells harboring T790M/L858R mutant assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33556869]
In Vitro

Azalamellarin N (0.125-1 μM, pretreated 30 min) attenuates ATP- and nigericin-induced pyroptosis and activation of the NLRP3 inflammasome[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azalamellarin N Related Antibodies

Western Blot Analysis[1]

Cell Line: THP-1, J774.1
Concentration: 0.125, 0.25, 0.5, 1 μM
Incubation Time: pretreated 30 min
Result: Strongly inhibited ATP- and nigericin-induced IL-1β release, but only modestly inhibited R837-induced IL-1β release.
Inhibited Nigericin-induced cleavage of caspase-1.
Suppressed ATP-induced oligomerization of ASC to a similar extent to MCC950.
Molecular Weight

498.48

Formula

C28H22N2O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(C2=C(C(C=C(OC)C(O)=C3)=C3C=C4)N4C5=C2C6=C(C=C(O)C(OC)=C6)NC5=O)=CC=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Azalamellarin N Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azalamellarin N1809535-57-6AZL-NPyroptosisPyroptosis inhibitioninflammasomeinflammasome assemblyNLRP3Inhibitorinhibitorinhibit

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