Galactokinase

Galactokinase; GALK; GAL; GALK1; GAL1

Galactokinase is a key enzyme involved in galactose metabolism, mainly responsible for phosphorylating galactose to galactose-1-phosphate. Galactokinasedysfunction leads to metabolic disorders such as the autosomal recessive genetic disease galactosemia, in which abnormal metabolized galactose and its metabolite accumulates in the body, causing probably intellectual disability, liver dysfunction and cataracts^[1].

References:

[1]. Holden HM, et al., Galactokinase: structure, function and role in type II galactosemia. Cell Mol Life Sci. 2004 Oct;61(19-20):2471-84. [Content Brief]

Galactokinase Inhibitor (1)

Galactokinase Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-173642

NCGC00238624	Inhibitor
NCGC00238624 is a selective galactokinase (GALK1) inhibitor with IC₅₀s of 7.69 μM and 13.67 μM against the human and mouse recombinant GALK1, respectively. NCGC00238624 is inactive against GALK2 and other kinases at 10 μM. NCGC00238624 can be used for the study of classic galactosemia.

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