2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Liposome Interleukin Related IFNAR
  4. Vaxfectin

Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation.

For research use only. We do not sell to patients.

Vaxfectin Chemical Structure

Vaxfectin Chemical Structure

CAS No. : 370108-99-9

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Based on 1 publication(s) in Google Scholar

Vaxfectin Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation[1][2][3].

In Vitro

Vaxfectin formulated pDNA induces both IL-6 and IFN-γ production by cultured splenocytes from BALB/c mice within 24 h[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vaxfectin Related Antibodies
In Vivo

Vaxfectin (i.m., single dose) formulated VR4700 (5-25 μg) produces a significant increase in anti-nuclear protein (NP) at 5 μg and significantly enhances antibody titers at 25 μg in mice[2].
Vaxfectin (i.m., single dose) formulated VR4700 (25 μg per muscle) results in stronger CTL responses in mice[2].
Vaxfectin (i.m., single dose) formulated VR4700 (5 μg) increases the number of antigen-specific plasma cells in bone marrow[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1450.05

Formula

C81H163BrN3O10P
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

NCCOP(OC[C@H](OC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)COC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)(O)=O.CCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)CCCN)OCCCCCCCC/C=C\CCCC.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (68.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6896 mL 3.4482 mL 6.8963 mL
5 mM 0.1379 mL 0.6896 mL 1.3793 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6896 mL 3.4482 mL 6.8963 mL 17.2408 mL
5 mM 0.1379 mL 0.6896 mL 1.3793 mL 3.4482 mL
10 mM 0.0690 mL 0.3448 mL 0.6896 mL 1.7241 mL
15 mM 0.0460 mL 0.2299 mL 0.4598 mL 1.1494 mL
20 mM 0.0345 mL 0.1724 mL 0.3448 mL 0.8620 mL
25 mM 0.0276 mL 0.1379 mL 0.2759 mL 0.6896 mL
30 mM 0.0230 mL 0.1149 mL 0.2299 mL 0.5747 mL
40 mM 0.0172 mL 0.0862 mL 0.1724 mL 0.4310 mL
50 mM 0.0138 mL 0.0690 mL 0.1379 mL 0.3448 mL
60 mM 0.0115 mL 0.0575 mL 0.1149 mL 0.2873 mL
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Vaxfectin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vaxfectin370108-99-9LiposomeInterleukin RelatedIFNARILInterferon-α/β receptorInterferon-alpha/beta receptoradjuvantvaccinesInhibitorinhibitorinhibit

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