2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. UNC8212

UNC8212 is a TAM kinase inhibitor. UNC8212 has potent inhibitory activity against MERTK and AXL (IC50: 1.5 nM and 1.3 nM, respectively), and also inhibits TYRO3 (IC50: 6.7 nM). UNC8212 mediates polypharmacological properties by targeting the structurally diverse "back pocket" region of the TAM kinase family. UNC8212 binds tightly to TAM kinases and potently inhibits MERTK and AXL phosphorylation. UNC8212 has anti-tumor effects and can be used in cancer immunotherapy and tumor cell targeting research.

For research use only. We do not sell to patients.

UNC8212 Chemical Structure

UNC8212 Chemical Structure

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UNC8212 Related Antibodies

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Axl Mer Tyro3

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Description

UNC8212 is a TAM kinase inhibitor. UNC8212 has potent inhibitory activity against MERTK and AXL (IC50: 1.5 nM and 1.3 nM, respectively), and also inhibits TYRO3 (IC50: 6.7 nM). UNC8212 mediates polypharmacological properties by targeting the structurally diverse "back pocket" region of the TAM kinase family. UNC8212 binds tightly to TAM kinases and potently inhibits MERTK and AXL phosphorylation. UNC8212 has anti-tumor effects and can be used in cancer immunotherapy and tumor cell targeting research[1].

IC50 & Target[1]

Axl

1.3 nM (IC50)

MERTK

1.5 nM (IC50)

Tyro3

6.7 nM (IC50)

Molecular Weight

610.75

Formula

C34H42N8O3
SMILES

CC(C)C(NC1=CC(C#CC2=CC=C(NC3=NC(N[C@@H]4CC[C@@H](O)CC4)=C(C(NC5CCN(C)CC5)=O)C=N3)C=C2)=NC=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UNC8212 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC8212UNC 8212UNC-8212TAM ReceptorTyro3AxlMerTAM kinaseTYRO3AXLMERTKNSCLCanti-tumorcancerInhibitorinhibitorinhibit

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