2. Vitamin D Related/Nuclear Receptor Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Nuclear Hormone Receptor 4A/NR4A Ferroptosis Reactive Oxygen Species Glutathione Peroxidase
  4. Nur77 agonist-1

Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. Nur77 agonist-1 induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression. Nur77 agonist-1 has binding affinity to the ligand binding domain (LBD) of Nur77 (KD: 13.80 μM). Nur77 agonist-1 exhibits significant antiproliferative activity against a variety of breast cancer cells (IC50: 2.15-3.26 μM) and has low toxicity to normal cells. Nur77 agonist-1 can be used in breast cancer research.

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Nur77 agonist-1 Chemical Structure

Nur77 agonist-1 Chemical Structure

CAS No. : 2899254-71-6

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Nur77 agonist-1 Related Antibodies

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Nur77/NR4A1 Nurr1/NR4A2

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Description

Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. Nur77 agonist-1 induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression. Nur77 agonist-1 has binding affinity to the ligand binding domain (LBD) of Nur77 (KD: 13.80 μM). Nur77 agonist-1 exhibits significant antiproliferative activity against a variety of breast cancer cells (IC50: 2.15-3.26 μM) and has low toxicity to normal cells. Nur77 agonist-1 can be used in breast cancer research[1].

Molecular Weight

443.89

Formula

C24H18ClN5O2
CAS No.
SMILES

O=C(NC1=CC=C(C(N/N=C/C2=CC=CC(Cl)=C2)=O)C=C1)NC3=CC4=CC=CN=C4C=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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Nur77 agonist-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nur77 agonist-12899254-71-6Nuclear Hormone Receptor 4A/NR4AFerroptosisReactive Oxygen SpeciesGlutathione PeroxidaseNuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptorcancerHaCaT cellsMCF-10A cellsNur77Inhibitorinhibitorinhibit

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