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M<sub>2</sub>-adrenoceptor

" in MedChemExpress (MCE) Product Catalog:

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γ-secretase (1)
By Research Areas:	Cancer (2758) Cardiovascular Disease (656) Endocrinology (480) Infection (1037) Inflammation/Immunology (889) Metabolic Disease (731) Neurological Disease (1176)
Click Chemistry:	ADC Synthesis (1) Labeling and Fluorescence Imaging (1) TCO (1) DBCO (5) PROTAC Synthesis (42) Azide (34) Alkynes (43)
Oligonucleotides:	miRNA mimics (4) Guanosine (2) Nucleotide Analogs (2) Flavoring Agents (1) Phospholipids (1) Cap Analogs (32) Antisense Oligonucleotides (1) siRNAs (42) pH Modifiers (1) Pegylated Lipids (6) Nucleoside Analogs (13) Mouse Pre-designed siRNA Sets (11) Cationic Lipids (3) Adjuvant (5) Human Pre-designed siRNA Sets (20) Polymers (11) miRNA antagomirs (4) Adenosine (8) Nucleoside Phosphoramidites (1) Rat Pre-designed siRNA Sets (11) miRNA inhibitors (4) Cholesterol (1) miRNA agomirs (4) Guanine Nucleotide (2) MicroRNAs (16) Aptamers (4) CpG ODNs (4) Uridine (3) Uracil (1)

7664

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

138

Biochemical Assay Reagents

103

Peptides

MCE Kits

Inhibitory Antibodies

363

Natural
Products

545

Recombinant Proteins

4345

Isotope-Labeled Compounds

164

Antibodies

Click Chemistry

143

Oligonucleotides

Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-RS18793

Sub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Mouse Pre-designed siRNA Set A Sub1 Mouse Pre-designed siRNA Set A

HY-RS25282

Sub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Rat Pre-designed siRNA Set A Sub1 Rat Pre-designed siRNA Set A

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-16637S

Folic acid-d2 Vitamin B9-d<sub>2sub>; Vitamin M-d<sub>2sub>	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Folic acid-d₂ (Vitamin B9-d₂) is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-161763

Tubulin polymerization-IN-65	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-65 is a tubulin polymerisation inhibitor with a broad spectrum cytotoxic. Tubulin polymerization-IN-65 induces G2 + M cell cycle arrest .

HY-144220

NLRP3/AIM2-IN-1	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3/AIM2-IN-1 is a thermal sepsis inhibitor with an < b > IC < sub > 50 < / sub > < / b > value of 3.136 ± 0.7667 μ M.

HY-W751444

2,4-Dimethylanisole-13C6 4-Methoxy-m-xylene-¹³C<sub>6sub>	Isotope-Labeled Compounds	Others
2,4-Dimethylanisole- ¹³C₆ (4-Methoxy-m-xylene- ¹³C₆) is the ¹³C-labeled 2,4-Dimethylanisole (HY-W100677).

HY-Y0589S

m-Cyanobenzoic acid-13C6 3-Carboxybenzonitrile-¹³C<sub>6sub>; 3-Cyanobenzoic acid-¹³C<sub>6sub>; m-Carboxybenzonitrile-¹³C<sub>6sub>	Isotope-Labeled Compounds	Others
m-Cyanobenzoic acid- ¹³C₆ is the ¹³C labeled m-Cyanobenzoic acid .

HY-129336S

Abemaciclib metabolite M20-d8 LSN3106726-d<sub>8sub>	CDK	Cancer
Abemaciclib metabolite M20-d₈ is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor .

HY-107327S

Carazolol-d7 (±)-Carazolol-d<sub>7sub>; DL-Carazolol-d<sub>7sub>; Suacron-d<sub>7sub>	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor** agonist. Carazolol can be used in the research of hypertension .

HY-126534S

Abemaciclib metabolite M18-d8 LSN3106729-d<sub>8sub>	CDK Ligands for Target Protein for PROTAC	Cancer
Abemaciclib metabolite M18-d₈ is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader ^[2].

HY-128669S

Abemaciclib metabolite M2-d6 LSN2839567-d<sub>6sub>	CDK	Cancer
Abemaciclib metabolite M2-d₆ is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC₅₀s in the range of 1-3 nM. Anti-cancer activity ^[2].

HY-W855075A

Methyl coenzyme M ammonium	Biochemical Assay Reagents	Others
Methyl-coenzyme M can reversibly synthesize methane in methanogenic, ANME-1 and ANME-2 archaea under the catalysis of methyl-coenzyme M Reductase .

HY-W700392

IMPDH-IN-2	IMPDH	Cancer
IMPDH-IN-2 (compound 2) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH) with *IC_{50 for IMPDH I and IMPDH II >}*Values are 0.15 and 0.17 μM, respectively. IMPDH-IN-2 has antitumor activity .

HY-W717406

CH5468924-d4 Alectinib Metabolite M-4-d<sub>4sub>	Isotope-Labeled Compounds	Others
CH5468924-d₄ (Alectinib Metabolite M-4-d₄) is the deuterium labeled CH5468924.

HY-B0389S26

D-Glucose-d2-2 Glucose-d<sub>2sub>-2; D-(+)-Glucose-d<sub>2sub>-2; Dextrose-d<sub>2sub>-2	Endogenous Metabolite	Metabolic Disease Cancer
D-Glucose-d₂-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol

HY-W716702

Aldox-d6 Lexamine M-13-d<sub>6sub>; MAPD-d<sub>6sub>	Isotope-Labeled Compounds Fungal Bacterial Antibiotic Biochemical Assay Reagents Insecticide	Inflammation/Immunology
Aldox-d₆ (Lexamine M-13-d₆; MAPD-d₆) is the deuterium labeled Myristamidopropyl dimethylamine (HY-W099582). Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .

HY-W654076

Di-m-tolyl p-tolyl phosphate-d7 Bis(m-cresyl) p-Cresyl Phosphate-d<sub>7sub>	Isotope-Labeled Compounds	Others
Di-m-tolyl p-tolyl phosphate-d₇ (Bis(m-cresyl) p-Cresyl Phosphate-d₇) is the deuterium labeled Di-m-tolyl p-tolyl phosphate (HY-W710756).

HY-14728S

Deutaleglitazar Aleglitazar-d<sub>2sub>; R1439-d<sub>2sub>; RO0728804-d<sub>2sub>	PPAR	Others
Deutaleglitazar is a agonist of dual peroxisome proliferatory activating receptor (PPARα and PPARγ) .

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis	Cancer
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[2] .

HY-B0391S1

Naftopidil-d5 KT-611-d<sub>5sub>; BM-15275-d<sub>5sub>	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
Naftopidil-d₅ is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[2].

HY-Y0418S4

Dulcite-d2 Dulcitol-d<sub>2sub>; Melampyrit-d<sub>2sub>; NSC 1944-d<sub>2sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
Dulcite-d₂ is the deuterium labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact ^[2].

HY-B0010S

Formoterol-d6 (±)Formoterol-d<sub>6sub>	Isotope-Labeled Compounds Adrenergic Receptor	Inflammation/Immunology Endocrinology
Formoterol-d₆ is the deuterium labeled Formoterol. Formoterol ((±)Formoterol) is a potent, selective and long-acting β2-adrenoceptor agonist .

HY-158194

*α2C adrenoceptor* agonist 1**	Adrenergic Receptor	Cancer
α2C adrenoceptor agonist 1 (Compound A) is an orally active, highly selective, and non-central nervous system penetrating agonist for the *α2C-adrenoceptor, with EC₅₀* and K_i values of 108 nM and 12 nM, respectively. α2C adrenoceptor agonist 1 can be used in the study of nasal congestion .

HY-16637S1

Folic acid-d4 Vitamin B9-d<sub>4sub>; Vitamin M-d<sub>4sub>	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Folic acid-d₄ is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-W725472

1,3-Dibromobenzene-d4 m-Dibromobenzene-d<sub>4sub>	Isotope-Labeled Compounds	Others
1,3-Dibromobenzene-d₄ (m-Dibromobenzene-d₄) is the deuterium labeled 1,3-Dibromobenzene.

HY-B0688S3

Dapsone-15N2 4,4′-Diaminodiphenyl sulfone-¹⁵N<sub>2sub>; DDS-¹⁵N<sub>2sub>	Isotope-Labeled Compounds Antibiotic Reactive Oxygen Species (ROS) Bacterial Parasite	Infection Inflammation/Immunology
Dapsone- ¹⁵N₂ (4,4′-Diaminodiphenyl sulfone- ¹⁵N₂) is ¹⁵N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al ^[2] .

HY-B0389S22

D-Glucose-13C2,d2 Glucose-¹³C<sub>2sub>,d<sub>2sub>; D-(+)-Glucose-¹³C<sub>2sub>,d<sub>2sub>; Dextrose-¹³C<sub>2sub>,d<sub>2sub>	Endogenous Metabolite	Metabolic Disease Cancer
D-Glucose- ¹³C₂,d₂ is the deuterium and ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si

HY-B0400S9

D-Sorbitol-d2-2 Sorbitol-d<sub>2sub>-2; D-Glucitol-d<sub>2sub>-2	Endogenous Metabolite	Others
D-Sorbitol-d₂-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di

HY-B0141AS1

Alpha-Estradiol-d2 Alfatradiol-d<sub>2sub>; Epiestradiol-d<sub>2sub>; Epiestrol-d<sub>2sub>	5 alpha Reductase Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Alpha-Estradiol-d₂ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia .

HY-B0389S5

D-Glucose-d2 Glucose-d<sub>2sub>; D-(+)-Glucose-d<sub>2sub>; Dextrose-d<sub>2sub>	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₂2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0471S3

Phenylephrine-d6 hydrochloride (R)-(-)-Phenylephrine-d<sub>6sub> hydrochloride; L-Phenylephrine-d<sub>6sub> hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0391S2

Naftopidil-d7 KT-611-d<sub>7sub>; BM-15275-d<sub>7sub>	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
Naftopidil-d₇ (KT-611-d₇ ) is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[2].

HY-17034AS

Dexmedetomidine-13C,d3 hydrochloride (+)-Medetomidine-¹³C,d<sub>3sub> hydrochloride; (S)-Medetomidine-¹³C,d<sub>3sub> hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Dexmedetomidine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a K_i of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects ^[2] .

HY-W777166

Aprepitant-13C2,d2 (Major) MK-0869--¹³C<sub>2sub>,d<sub>2sub>; MK-869-¹³C<sub>2sub>,d<sub>2sub>; L-754030--¹³C<sub>2sub>,d<sub>2sub>	Isotope-Labeled Compounds HIV Antibiotic Neurokinin Receptor Bacterial	Neurological Disease Endocrinology Cancer
Aprepitant- ¹³C₂,d₂ (Major) (MK-0869- ¹³C₂,d₂) is ¹³C labeled Aprepitant. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K_d of 86 pM.

HY-77839S1

Cortodoxone-d2 11-Deoxycortisol-d<sub>2sub>; cortexolone-d<sub>2sub>; Reichstein's substance S-d<sub>2sub>	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone-d₂ is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone) .

HY-107542S2

Oleoylethanolamide-d2 N-Oleoylethanolamide-d<sub>2sub>; Oleamide MEA-d<sub>2sub>; Oleic acid monoethanolamide-d<sub>2sub>	Isotope-Labeled Compounds Endogenous Metabolite PPAR	Cardiovascular Disease Metabolic Disease
Oleoylethanolamide-d₂ is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.

HY-W338294S3

2'-Deoxycytidine-d2 monohydrate Deoxycytidine-d<sub>2sub> monohydrate; Cytosine deoxyriboside-d<sub>2sub> monohydrate; Deoxyribose cytidine-d<sub>2sub> monohydrate	Isotope-Labeled Compounds	Others
2'-Deoxycytidine-d₂ monohydrate is the deuterium labeled 2'-Deoxycytidine monohydrate .

HY-W744625

Olodaterol-d3 hydrochloride BI1744-d<sub>3sub> hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology
Olodaterol-d₃ hydrochloride (BI1744-d₃ hydrochloride) is the deuterium labeled Olodaterol hydrochloride (HY-14301A). Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC₅₀=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis ^[2] .

HY-B0471S

Phenylephrine-d3 hydrochloride (R)-(-)-Phenylephrine-d<sub>3sub> (hydrochloride); L-Phenylephrine-d<sub>3sub> (hydrochloride)	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-U00333

*α1 adrenoceptor-MO-1*	Adrenergic Receptor	Neurological Disease Endocrinology
α1 adrenoceptor-MO-1, an S enantiomer, has affinity at alpha 1 adrenergic receptor, shows alphalytic activity, and possesses analgesic action; more active than R enantiomer.

HY-116790BSA

(±)-Penbutolol-d9 hydrochloride (Rac)-Penbutolol-d<sub>9sub> hydrochloride; (±)-Isopenbutolol-d<sub>9sub> hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
(±)-Penbutolol-d₉ (hydrochloride) is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC₅₀ of 0.74 μM .

HY-165703S

Prothioconazole-S-methyl-d3 Prothioconazole-M01-d<sub>3sub>	Isotope-Labeled Compounds	Others
Prothioconazole-S-methyl-d₃ (Prothioconazole-M01-d₃) is deuterium labeled Prothioconazole-S-methyl .

HY-14773S3

Mirabegron-d5 YM178-d<sub>5sub>	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Mirabegron-d₅ (YM178-d₅) is deuterium labeled Mirabegron. Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

HY-14773S1

Mirabegron-d8 YM178-d<sub>8sub>	Isotope-Labeled Compounds	Neurological Disease Endocrinology Cancer
Mirabegron-d₈ (YM178-d₈) is deuterium labeled Mirabegron. Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

HY-144223

NLRP3/AIM2-IN-2 1 Publications Verification	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
NLRP3/aim2-in-2 (compound 8) is a new potent inhibitor with different species-specific effects on NLRP3 and *AIM2* inflammasome dependent cell death. Its < b > IC < sub > 50 < / sub > < / b > value is 0.2392 μ M。

HY-101047S1

D-erythro-Sphingosine-13C2,d2 Erythrosphingosine-¹³C<sub>2sub>,d<sub>2sub>; erythro-C18-Sphingosine-¹³C<sub>2sub>,d<sub>2sub>; trans-4-Sphingenine-¹³C<sub>2sub>,d<sub>2sub>	Isotope-Labeled Compounds PKC Endogenous Metabolite Phosphatase	Cancer
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator ^[2] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[2] .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[2] .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	Reference Standards NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[2] [4].

HY-N0662

Amentoflavone 10+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[2] .

HY-W011370

Pelargonidin chloride 1 Publications Verification	Structural Classification Anthocyans Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Phaseolus vulgaris Linn. Disease Research Fields	Quinone Reductase Reactive Oxygen Species (ROS)
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment ^[2] .

HY-125833R

Alpha-Naphthoflavone (Standard)	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone (Standard) is the analytical standard of Alpha-Naphthoflavone. This product is intended for research and analytical applications. Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[2] .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N15356

9-Oxooctadecanedioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Quercus suber L. Fagaceae	Bacterial
9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the cork suberin of Quercus suber. It contributes to the formation of the hydrophobic barrier structure in plant cell walls and may play an important role in functions such as water resistance and protection against microbial penetration .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-113357

m-Coumaric acid	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant. m-Coumaric acid is a BBB-penetrant metabolite of chlorogenic acid. m-Coumaric acid stimulates the cerebral nerves in vitro. m-Coumaric acid can evoke neurite outgrowth in hippocampal neuronal cells. m-Coumaric acid can promote neuronal differentiation. m-Coumaric acid increases spontaneous locomotor activity in mice by acting on the central nervous system. m-Coumaric acid inhibits the oxidation of L-dopa by epidermis tyrosinase. m-Coumaric acid attenuates non-catalytic protein glycosylation in retinas of diabetic rats ^[2] .

HY-N1529

Gomisin M1 (±)-Gomisin M1	Structural Classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC₅₀ of <0.65 μM .

HY-W011704A

Phosphoenolpyruvic acid tricyclohexylammonium salt 1 Publications Verification Phosphoenolpyruvate tricyclohexylammonium salt	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phosphoenolpyruvic acid (Phosphoenolpyruvate) tricyclohexylammonium salt is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid tricyclohexylammonium salt is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid tricyclohexylammonium salt also exhibits cytoprotective and anti-oxidative properties .

HY-113357R

m-Coumaric acid (Standard)	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Reference Standards Endogenous Metabolite
m-Coumaric acid (Standard) is the analytical standard of m-Coumaric acid. This product is intended for research and analytical applications. m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant. m-Coumaric acid is a BBB-penetrant metabolite of chlorogenic acid. m-Coumaric acid stimulates the cerebral nerves in vitro. m-Coumaric acid can evoke neurite outgrowth in hippocampal neuronal cells. m-Coumaric acid can promote neuronal differentiation. m-Coumaric acid increases spontaneous locomotor activity in mice by acting on the central nervous system. m-Coumaric acid inhibits the oxidation of L-dopa by epidermis tyrosinase. m-Coumaric acid attenuates non-catalytic protein glycosylation in retinas of diabetic rats ^[2] .

HY-P2274R

Argifin (Standard)	Structural Classification Natural Products Microorganisms Source classification	Reference Standards Parasite
Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

HY-N3963

Gomisin M2 (+)-Gomisin M2	Classification of Application Fields Neurological Disease Source classification Lignans Plants Infection Monophenols Phenols Phenylpropanoids Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.	HIV
Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra rubriflora with anti-HIV activity (EC₅₀ of 2.4 μM). Gomisin M2 exhibits anti-cancer and anti-allergic activities and has the potential for Alzheimer’s disease research ^[2].

HY-122493

Illudin M	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	DNA Alkylator/Crosslinker Apoptosis
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities ^[2].

HY-117220

Aspochalasin M	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Others
Aspochalasin M is a colorless solid. Aspochalasin M shows modest activity against HL-60 cells with an IC₅₀ of 20.0 μM. Aspochalasin M has the potential for the research of leukemic disease .

HY-130596

DC-86-M	Structural Classification Microorganisms Antibiotics Source classification Disease Research Anticancer	Antibiotic Bacterial
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD₅₀ of 25 mg/kg .

HY-N14783

Decarestrictin M	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Endogenous Metabolite
Decarestrictin M is a decanolactone that can be isolated from penicillium strains. Decarestrictin M is an inhibitor of cholesterol biosynthesis .

HY-N8956

Pachysamine M	Structural Classification Alkaloids Buxaceae Other Alkaloids Source classification Pachysandra terminalis Siebold & Zucc. Plants	Others
Pachysamine M (Compound 5) is a pregnane alkaloid. Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .

HY-113356

m-Tyramine	Monophenols Source classification Disease markers Phenols Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
m-Tyramine is an endogenous trace amine neuromodulator. m-Tyramine has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-N2244

Hosenkoside M (+)-Hosenkoside M	Triterpenes Structural Classification Classification of Application Fields Terpenoids Impatiens balsamina Linn. Source classification Balsaminaceae Plants Inflammation/Immunology Disease Research Fields	Others
Hosenkoside M is a baccharane glycoside isolated from the seeds of impatiens balsamina.

HY-N4251

Periplocoside M (-)-Periplocoside M	Structural Classification Natural Products Source classification Asclepiadaceae Plants Periploca sepium Bunge	Others
Periplocoside M (compound 8) is a natural product isolated from the root bark of Periploca sepium. Periplocoside M shows antitumor activity against human A-549 and HepG2 cell lines, with the IC₅₀ of 4.84 and 7.06 μM .

HY-N6833

Rebaudioside M	Structural Classification Classification of Application Fields Source classification Plants Compositae Sweeteners Food Research Trifolium hybridum L. other families Terpenoids Other Diseases Diterpenoids Disease Research Fields	Others
Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage ^[2] .

HY-N0662R

Amentoflavone (Standard) Didemethyl-ginkgetin (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reference Standards Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[2] .

HY-N10640

Alismanol M	Triterpenes Terpenoids Alisma orinentale (Samuel.) Juz. Plants Alismataceae	FXR
Alismanol M is a farnesoid X receptor (FXR) agonist with an EC₅₀ value of 50.25 μM. Alismanol M is a protostane-type triterpenoid that can be isolated from the rhizome of Alisma orientale. Alismanol M can be used for the research of cholestasis and nonalcoholic steatohepatitis .

HY-N15513

Harzianol M	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	NO Synthase
Harzianol M is found in Trichoderma sp. SCSIOW21. Harzianol M can inhibit the production of NO and exhibit anti-inflammatory activity .

HY-N6833R

Rebaudioside M (Standard)	Structural Classification Trifolium hybridum L. other families Terpenoids Source classification Diterpenoids Plants Compositae	Reference Standards Others
Rebaudioside M (Standard) is the analytical standard of Rebaudioside M. This product is intended for research and analytical applications. Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M is more than 350 times sweeter than sucrose ^[2].

HY-N11443

Acetyllycoposerramine M	Lycopodiaceae Structural Classification Alkaloids Source classification Palhinhaea cernua (L.) Vasc. et Franco Plants	Others
Acetyllycoposerramine M is a lycopodine-type alkaloid, which can be isolated from Lycopodium japonicum. But Acetyllycoposerramine M has no inhibitory effect on acetylcholinesterase .

HY-129306

Gilvocarcin M	Structural Classification Microorganisms Source classification Coumarins Phenylpropanoids	Antibiotic Bacterial
Gilvocarcin M is an antibiotic and can be isolated from S. gilvotanareus. Gilvocarcin M is active against S. aureus at a concentration of 32 µg/ml and inhibits growth of KB cells with the IC₅₀ of 0.52 µg/ml. Gilvocarcin M intercalates into bacteriophage PM2 DNA ^[2] .

HY-N7127R

(E)-m-Coumaric acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Reference Standards Endogenous Metabolite
(E)-m-Coumaric acid (Standard) is the analytical standard of (E)-m-Coumaric acid. This product is intended for research and analytical applications. (E)-m-Coumaric acid (3-Hydroxycinnamic acid) is an aromatic acid that highly abundant in food. (E)-m-Coumaric acid (3-Hydroxycinnamic acid) is an antioxidant.

HY-128975R

m-Tyramine hydrobromide (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
m-Tyramine (hydrobromide) (Standard) is the analytical standard of m-Tyramine (hydrobromide). This product is intended for research and analytical applications. m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor[1, 2].

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Payload Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis ^[2] .

HY-128975

m-Tyramine hydrobromide	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-N7127

(E)-m-Coumaric acid	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
(E)-m-Coumaric acid (3-Hydroxycinnamic acid) is an aromatic acid that highly abundant in food. (E)-m-Coumaric acid (3-Hydroxycinnamic acid) is an antioxidant.

HY-N8049

Urolithin M7	Structural Classification Natural Products Microorganisms Animals Source classification	Endogenous Metabolite
Urolithin M7 is an orally active metabolite, which is generated through gut microbiota metabolism. Urolithin M7 inhibits oxidative stress and modulates inflammatory signaling pathways. Urolithin M7 is promising for research of gut microbiota metabolism and cardiovascular diseases .

HY-78086

m-Tolualdehyde 3-Methylbenzaldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Source classification Other Diseases Plants Disease Research Fields Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Endogenous Metabolite Bacterial
m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD₅₀ of 1.97 μg/cm ³ ^[2].

HY-N8094

Kushenol M	Flavanonols Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields	Cytochrome P450
Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC₅₀ values of 1.29 μM for CYP3A4 in human liver microsomes .

HY-W015343

3-Methoxyphenylacetic acid m-Methoxyphenylacetic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot .

HY-W001940

DL-m-Tyrosine	Cardiovascular Disease Structural Classification Monophenols Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Drug Derivative
DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect ^[2].

HY-N12179

Brevianamide M	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Other Alkaloids Source classification Endogenous metabolite	Bacterial
Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .

HY-N11079

Toonaciliatin M	Structural Classification Terpenoids Source classification Toona ciliata var. pubescens Diterpenoids Plants Meliaceae	Fungal
Toonaciliatin M (compound 6) is a pmaradiene-type diterpenoid that can be isolated from Toona ciliate. Toonaciliatin M show antifungal activity against Trichophyton rubrum with an MIC value of 12.5 µg/mL .

HY-N7921

Urolithin M6	Structural Classification Monophenols Source classification Phenols Endogenous metabolite	Bacterial
Urolithin M6 is a polyhydroxy-rich metabolite with potential antioxidant activity. Urolithin M6 is produced by intestinal microbial metabolism and may act as an analog of tannic acid compounds. The production of Urolithin M6 in humans requires specific bacterial 3-dehydroxylase activity, which provides a new mechanism for its biotransformation. The metabolic profile of Urolithin M6 helps to stratify volunteers and further explore its potential role in health and disease .

HY-W007346R

m-Anisaldehyde (Standard) 3-Methoxybenzaldehyde (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite	Reference Standards Endogenous Metabolite
m-Anisaldehyde (Standard) is the analytical standard of m-Anisaldehyde. This product is intended for research and analytical applications. m-Anisaldehyde is an endogenous metabolite.

HY-N14180

6-Deoxyilludin M	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic
6-Deoxyilludin M is an antitumor antibiotic possessing antileukemic activity. 6-Deoxyilludin M can be isolated from the culture broth of the Basidiomycota Pleurotus japonicas .

HY-N7922

Urolithin M5 Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Source classification Phenols Polyphenols Plants Burseraceae	Influenza Virus
Urolithin M5 is a neuraminidase inhibitor that can be isolated from Ganlanye. Urolithin M5 has antiviral activity in vitro and in vivo by inhibiting the activity of viral NA. Urolithin M5 can increase the survival rate and improve pulmonary edema in pr8-infected mouse models. Urolithin M5 can be used in anti-influenza research .

HY-133097

Yadanzioside M	Triterpenes Simaroubaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	Others
Yadanzioside M is a natural compound with anti-cancer activity .

HY-N12544

Magnoloside M	Structural Classification Magnolia utilis (Dandy) V.S.Kumar Source classification Magnoliaceae Phenols Polyphenols Plants	Others
Magnoloside M is a magnoside isolated from magnolia ^[2].

HY-78086R

m-Tolualdehyde (Standard) 3-Methylbenzaldehyde (Standard)	Structural Classification Ketones, Aldehydes, Acids Labiatae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Reference Standards Endogenous Metabolite Bacterial
m-Tolualdehyde (Standard) is the analytical standard of m-Tolualdehyde. This product is intended for research and analytical applications. m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD₅₀ of 1.97 μg/cm ³ ^[2].

Cat. No.	Product Name	Chemical Structure

HY-129336S

Abemaciclib metabolite M20-d8
Abemaciclib metabolite M20-d₈ is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor .

HY-107327S

Carazolol-d7
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor** agonist. Carazolol can be used in the research of hypertension .

HY-126534S

Abemaciclib metabolite M18-d8
Abemaciclib metabolite M18-d₈ is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader ^[2].

HY-128669S

Abemaciclib metabolite M2-d6
Abemaciclib metabolite M2-d₆ is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC₅₀s in the range of 1-3 nM. Anti-cancer activity ^[2].

HY-W717406

CH5468924-d4
CH5468924-d₄ (Alectinib Metabolite M-4-d₄) is the deuterium labeled CH5468924.

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-16637S

Folic acid-d2
Folic acid-d₂ (Vitamin B9-d₂) is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-W751444

2,4-Dimethylanisole-13C6
2,4-Dimethylanisole- ¹³C₆ (4-Methoxy-m-xylene- ¹³C₆) is the ¹³C-labeled 2,4-Dimethylanisole (HY-W100677).

HY-Y0589S

m-Cyanobenzoic acid-13C6
m-Cyanobenzoic acid- ¹³C₆ is the ¹³C labeled m-Cyanobenzoic acid .

HY-B0389S26

D-Glucose-d2-2
D-Glucose-d₂-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling mol

HY-W716702

Aldox-d6

Aldox-d₆ (Lexamine M-13-d₆; MAPD-d₆) is the deuterium labeled Myristamidopropyl dimethylamine (HY-W099582). Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .

HY-W654076

Di-m-tolyl p-tolyl phosphate-d7
Di-m-tolyl p-tolyl phosphate-d₇ (Bis(m-cresyl) p-Cresyl Phosphate-d₇) is the deuterium labeled Di-m-tolyl p-tolyl phosphate (HY-W710756).

HY-14728S

Deutaleglitazar
Deutaleglitazar is a agonist of dual peroxisome proliferatory activating receptor (PPARα and PPARγ) .

HY-B0391S1

Naftopidil-d5
Naftopidil-d₅ is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[2].

HY-Y0418S4

Dulcite-d2
Dulcite-d₂ is the deuterium labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact ^[2].

HY-B0010S

Formoterol-d6
Formoterol-d₆ is the deuterium labeled Formoterol. Formoterol ((±)Formoterol) is a potent, selective and long-acting β2-adrenoceptor agonist .

HY-16637S1

Folic acid-d4
Folic acid-d₄ is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-W725472

1,3-Dibromobenzene-d4
1,3-Dibromobenzene-d₄ (m-Dibromobenzene-d₄) is the deuterium labeled 1,3-Dibromobenzene.

HY-B0688S3

Dapsone-15N2

Dapsone- ¹⁵N₂ (4,4′-Diaminodiphenyl sulfone- ¹⁵N₂) is ¹⁵N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al ^[2] .

HY-B0389S22

D-Glucose-13C2,d2
D-Glucose- ¹³C₂,d₂ is the deuterium and ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si

HY-B0400S9

D-Sorbitol-d2-2
D-Sorbitol-d₂-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di

HY-B0141AS1

Alpha-Estradiol-d2
Alpha-Estradiol-d₂ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia .

HY-B0389S5

D-Glucose-d2
D-Glucose-d₂2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0471S3

Phenylephrine-d6 hydrochloride
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0391S2

Naftopidil-d7
Naftopidil-d₇ (KT-611-d₇ ) is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[2].

HY-17034AS

Dexmedetomidine-13C,d3 hydrochloride

Dexmedetomidine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a K_i of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects ^[2] .

HY-W777166

Aprepitant-13C2,d2 (Major)
Aprepitant- ¹³C₂,d₂ (Major) (MK-0869- ¹³C₂,d₂) is ¹³C labeled Aprepitant. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K_d of 86 pM.

HY-77839S1

Cortodoxone-d2
Cortodoxone-d₂ is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone) .

HY-107542S2

Oleoylethanolamide-d2
Oleoylethanolamide-d₂ is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.

HY-W338294S3

2'-Deoxycytidine-d2 monohydrate
2'-Deoxycytidine-d₂ monohydrate is the deuterium labeled 2'-Deoxycytidine monohydrate .

HY-W744625

Olodaterol-d3 hydrochloride
Olodaterol-d₃ hydrochloride (BI1744-d₃ hydrochloride) is the deuterium labeled Olodaterol hydrochloride (HY-14301A). Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC₅₀=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis ^[2] .

HY-B0471S

Phenylephrine-d3 hydrochloride
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-116790BSA

(±)-Penbutolol-d9 hydrochloride
(±)-Penbutolol-d₉ (hydrochloride) is a deuterium labeled (±)-Penbutolol hydrochloride. (+)-Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC₅₀ of 0.74 μM .

HY-165703S

Prothioconazole-S-methyl-d3
Prothioconazole-S-methyl-d₃ (Prothioconazole-M01-d₃) is deuterium labeled Prothioconazole-S-methyl .

HY-14773S3

Mirabegron-d5
Mirabegron-d₅ (YM178-d₅) is deuterium labeled Mirabegron. Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

HY-14773S1

Mirabegron-d8
Mirabegron-d₈ (YM178-d₈) is deuterium labeled Mirabegron. Mirabegron is a selective *β₃-adrenoceptor* agonist with EC₅₀ of 22.4 nM.

HY-101047S1

D-erythro-Sphingosine-13C2,d2
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator ^[2] .

HY-B0511S2

Biotin-d2
Biotin-d₂ is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-W708653

(3-Phenoxyphenyl)methanol-d5
(3-Phenoxyphenyl)methanol-d₅ (m-Phenoxybenzyl alcohol-d₅) is the deuterium labeled (3-Phenoxyphenyl)methanol (HY-W014898).

HY-B1506AS

Acepromazine-d6 maleate
Acepromazine-d₆ (maleate) (Acetopromazine-d₆ (maleate)) is deuterium labeled Acepromazine (maleate). Acepromazine (Acetopromazine) maleate is a phenothiazine tranquilizer and is *alpha-adrenoceptor* antagonist ^[2.

HY-14773S

(Rac)-Mirabegron-d5
(Rac)-Mirabegron-d₅ is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selective β3-adrenoceptor agonist .

HY-N0378S4

D-Mannitol-d2
D-Mannitol-d₂ is the deuterium labeled D-Mannitol.

HY-B0234S1

Estrone-d2
Estrone-d₂ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[2].

HY-N1150S6

Thymidine-d2
Thymidine-d₂ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1

HY-13632S

Exemestane-d2
Exemestane-d₂ is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC₅₀s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research ^[2].

HY-B0246S1

Carbamazepine-d2
Carbamazepine-d₂ is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent.

HY-108226S

Regorafenib N-oxide and N-desmethyl (M5)-d3
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-B0352S2

Mirtazapine-d4
Mirtazapine-d₄ is deuterium labeled Mirtazapine. Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively ^[2].

HY-17501S

Bambuterol-d9 hydrochloride
Bambuterol-d₉ (hydrochloride) is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.

HY-B0141S3

Estradiol-d2
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway ^[2] .

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