2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Milameline hydrochloride

Milameline hydrochloride  (Synonyms: CI 979 hydrochloride; RU 35926 hydrochloride)

Cat. No.: HY-107650
Handling Instructions Technical Support

Milameline (CI 979; RU35926) hydrochloride is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydrochloride has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydrochloride has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydrochloride produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydrochloride can be used for the study of Alzheimer’s Disease.

For research use only. We do not sell to patients.

Milameline hydrochloride

Milameline hydrochloride Chemical Structure

CAS No. : 139886-04-7

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Milameline hydrochloride Related Antibodies

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Description

Milameline (CI 979; RU35926) hydrochloride is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydrochloride has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydrochloride has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydrochloride produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydrochloride can be used for the study of Alzheimer’s Disease[1].

IC50 & Target[1]

mAChR1

1.3 μM (IC50)

mAChR2

1.1 μM (IC50)

mAChR3

1.5 μM (IC50)

mAChR4

1.9 μM (IC50)

In Vitro

Milameline hydrochloride increases soluble APP (sAPP) secretion in CHO cells transfected with human M1 or M3 receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Milameline hydrochloride Related Antibodies
In Vivo

Milameline (0.2 mg/kg (rat), p.o., or 0.01 mg/kg (monkey), i.m., single dose) hydrochloride produces central effects (hypothermia) in rats and central cholinergic effects in monkeys (increased neocortical arousal in the electroencephalogram (EEG))[1].
Milameline (0.02- > 0.1 mg/kg, p.o.) hydrochloride effectively reverses scopolamine-induced working memory impairment in rats at low doses (0.02-0.1 mg/kg), but the effect is reduced at high doses (> 0.1 mg/kg)[1].
Milameline hydrochloride increases cerebral blood flow in rats, and its distribution in the brain is consistent with the areas where the cholinergic system is enriched[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

190.67

Formula

C8H15ClN2O
CAS No.
SMILES

CO/N=C/C1=CCCN(C)C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Milameline hydrochloride Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Milameline139886-04-7CI 979RU 35926CI979CI-979RU35926RU-35926mAChRMuscarinic acetylcholine receptorAlzheimer’s diseaseMuscarinic receptor agonistTetrahydropyridine aldoximePD-129409Inhibitorinhibitorinhibit

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