2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Milameline hydroiodide

Milameline hydroiodide  (Synonyms: CI 979 hydroiodide; RU 35926 hydroiodide)

Cat. No.: HY-107650A Purity: 96.25%
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Milameline (CI 979; RU35926) hydroiodide is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydroiodide has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydroiodide has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydroiodide produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydroiodide can be used for the study of Alzheimer’s Disease.

For research use only. We do not sell to patients.

Milameline hydroiodide

Milameline hydroiodide Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Milameline hydroiodide:

Milameline hydroiodide Related Antibodies

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Description

Milameline (CI 979; RU35926) hydroiodide is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydroiodide has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydroiodide has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydroiodide produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydroiodide can be used for the study of Alzheimer’s Disease[1].

IC50 & Target[1]

mAChR1

1.3 μM (IC50)

mAChR2

1.1 μM (IC50)

mAChR3

1.5 μM (IC50)

mAChR4

1.9 μM (IC50)

In Vitro

Milameline hydroiodide increases soluble APP (sAPP) secretion in CHO cells transfected with human M1 or M3 receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Milameline hydroiodide Related Antibodies
In Vivo

Milameline (0.2 mg/kg (rat), p.o., or 0.01 mg/kg (monkey), i.m., single dose) hydroiodide produces central effects (hypothermia) in rats and central cholinergic effects in monkeys (increased neocortical arousal in the electroencephalogram (EEG))[1].
Milameline (0.02- > 0.1 mg/kg, p.o.) hydroiodide effectively reverses scopolamine-induced working memory impairment in rats at low doses (0.02-0.1 mg/kg), but the effect is reduced at high doses (> 0.1 mg/kg)[1].
Milameline hydroiodide increases cerebral blood flow in rats, and its distribution in the brain is consistent with the areas where the cholinergic system is enriched[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

282.12

Formula

C8H15IN2O
Appearance

Solid

Color

Yellow to orange

SMILES

CO/N=C/C1=CCCN(C)C1.I
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Milameline hydroiodide Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Milameline hydroiodideCI 979 hydroiodideRU 35926 hydroiodidemAChRMuscarinic acetylcholine receptorAlzheimer’s diseaseMuscarinic receptor agonistTetrahydropyridine aldoximeMilamelineCI-979RU-35926PD-129409Inhibitorinhibitorinhibit

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