2. MAPK/ERK Pathway Apoptosis
  3. p38 MAPK JNK Caspase Apoptosis
  4. MKK7-JNK activator 1

MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator. MKK7-JNK activator 1 effectively inhibits the proliferation and migration of MDA-MB-468 cells, induces G2/M phase arrest and caspase -dependent apoptosis (independent of ROS production). MKK7-JNK activator 1 significantly increases the levels of p-MKK7 and p-JNK, but does not affect p-ERK or p-p38. MKK7-JNK activator 1 can be used for the study of triple-negative breast cancer (TNBC).

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MKK7-JNK activator 1

MKK7-JNK activator 1 Chemical Structure

CAS No. : 3100092-62-1

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MKK7-JNK activator 1 Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator. MKK7-JNK activator 1 effectively inhibits the proliferation and migration of MDA-MB-468 cells, induces G2/M phase arrest and caspase -dependent apoptosis (independent of ROS production). MKK7-JNK activator 1 significantly increases the levels of p-MKK7 and p-JNK, but does not affect p-ERK or p-p38. MKK7-JNK activator 1 can be used for the study of triple-negative breast cancer (TNBC)[1].

IC50 & Target[1]

Caspase 3

 

Caspase 8

 

Caspase 9

 

Molecular Weight

533.00

Formula

C17H12Br2INO
CAS No.
SMILES

CC1=NC2=C(OCC3=CC=CC(I)=C3)C(Br)=CC(Br)=C2C=C1
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Purity & Documentation
References
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MKK7-JNK activator 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MKK7-JNK activator 13100092-62-1p38 MAPKJNKCaspaseApoptosisc-Jun N-terminal kinase8-HydroxyquinolineBroquinaldolJNK pathwayTriple negative breast CancerInhibitorinhibitorinhibit

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