2. Epigenetics Apoptosis
  3. YTHDF Apoptosis
  4. SKLB-Y13

SKLB-Y13 is a selective YTHDF1 inhibitor with an IC50 of 0.76  μM. SKLB-Y13 binds to the m6A recognition pocket and disrupts m6A-dependent YTHDF1-PRPF6 mRNA interaction, impairing the translation of PRPF6 and inhibiting breast cancer proliferation while promoting apoptosis. SKLB-Y13 has antitumor activity, promising for cancers therapies targeting RNA epigenetic Readers.

For research use only. We do not sell to patients.

SKLB-Y13

SKLB-Y13 Chemical Structure

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SKLB-Y13 Related Antibodies

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YTHDF1 YTHDF3 YTHDF2 YTHDC1 YTHDC2

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Description

SKLB-Y13 is a selective YTHDF1 inhibitor with an IC50 of 0.76  μM. SKLB-Y13 binds to the m6A recognition pocket and disrupts m6A-dependent YTHDF1-PRPF6 mRNA interaction, impairing the translation of PRPF6 and inhibiting breast cancer proliferation while promoting apoptosis. SKLB-Y13 has antitumor activity, promising for cancers therapies targeting RNA epigenetic Readers[1].

IC50 & Target[1]

YTHDF1

0.76 μM (IC50)

YTHDF2

4.27 μM (IC50)

YTHDF3

6.17 μM (IC50)

Molecular Weight

514.43

Formula

C23H21Cl2N7OS
SMILES

ClC1=CN=C(N=C1NC2=C(C3=C(S2)CN(CC3)CC4=CC=CC=C4Cl)C(N)=O)C5=CC=NN5C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SKLB-Y13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKLB-Y13YTHDFApoptosis(YTH) domain-containing family proteins (YTHDF)YTHDF1m6AYTHDF1-PRPF6 mRNA interactionAntitumorBreast cancerRNA epigenetic ReadersInhibitorinhibitorinhibit

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