2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. AC-42 hydrochloride

AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806). AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP)-accumulation and calcium mobilization in CHO cells.

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AC-42 hydrochloride

AC-42 hydrochloride Chemical Structure

CAS No. : 447407-36-5

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Other Forms of AC-42 hydrochloride:

AC-42 hydrochloride Related Antibodies

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Description

AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806). AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP)-accumulation and calcium mobilization in CHO cells[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
0.21 μM
Compound: AC-42
Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
[PMID: 22329602]
HEK293 EC50
0.45 μM
Compound: AC-42
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
[PMID: 22329602]
HEK293 EC50
0.72 μM
Compound: AC-42
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
[PMID: 22329602]
HEK293 EC50
0.74 μM
Compound: AC-42
Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
[PMID: 22329602]
Molecular Weight

337.93

Formula

C20H32ClNO
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(C1=CC=CC=C1C)CCCN2CCC(CCCC)CC2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (147.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9592 mL 14.7960 mL 29.5919 mL
5 mM 0.5918 mL 2.9592 mL 5.9184 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9592 mL 14.7960 mL 29.5919 mL 73.9798 mL
5 mM 0.5918 mL 2.9592 mL 5.9184 mL 14.7960 mL
10 mM 0.2959 mL 1.4796 mL 2.9592 mL 7.3980 mL
15 mM 0.1973 mL 0.9864 mL 1.9728 mL 4.9320 mL
20 mM 0.1480 mL 0.7398 mL 1.4796 mL 3.6990 mL
25 mM 0.1184 mL 0.5918 mL 1.1837 mL 2.9592 mL
30 mM 0.0986 mL 0.4932 mL 0.9864 mL 2.4660 mL
40 mM 0.0740 mL 0.3699 mL 0.7398 mL 1.8495 mL
50 mM 0.0592 mL 0.2959 mL 0.5918 mL 1.4796 mL
60 mM 0.0493 mL 0.2466 mL 0.4932 mL 1.2330 mL
80 mM 0.0370 mL 0.1849 mL 0.3699 mL 0.9247 mL
100 mM 0.0296 mL 0.1480 mL 0.2959 mL 0.7398 mL
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AC-42 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-42447407-36-5AC42AC 42mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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