AC-42 hydrochloride

Cat. No.: HY-118806A Purity: 98.42%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806). AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC₅₀s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP)-accumulation and calcium mobilization in CHO cells.

For research use only. We do not sell to patients.

AC-42 hydrochloride Chemical Structure

CAS No. : 447407-36-5

Size		Stock
5 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of AC-42 hydrochloride:

AC-42 Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mAChR Isoform Specific Products:

View All Isoforms

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.21 μM Compound: AC-42	Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay	[PMID: 22329602]
HEK293	EC₅₀	0.45 μM Compound: AC-42	Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay	[PMID: 22329602]
HEK293	EC₅₀	0.72 μM Compound: AC-42	Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay	[PMID: 22329602]
HEK293	EC₅₀	0.74 μM Compound: AC-42	Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay	[PMID: 22329602]

Molecular Weight

337.93

Formula

C₂₀H₃₂ClNO

CAS No.

447407-36-5

Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(C1=CC=CC=C1C)CCCN2CCC(CCCC)CC2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.42%

Select Batch:

Data Sheet (264 KB) SDS (393 KB)

COA (243 KB) HNMR (282 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78(4):648-57. [Content Brief]

[2]. Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69(1):236-46. [Content Brief]