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  4. Anti-Mouse/Human CD11b Antibody (M1/70)

Anti-Mouse/Human CD11b Antibody (M1/70) 

Cat. No.: HY-P99121 Purity: 95.00%
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Anti-Mouse/Human CD11b Antibody (M1/70) is an anti-mouse CD11b IgG2b monoclonal antibody. Anti-Mouse/Human CD11b Antibody (M1/70) can significantly inhibit the adhesion between dendritic cells (DCs) and platelets. Anti-Mouse/Human CD11b Antibody (M1/70) can kill ovarian cancer cells and inhibit their migration. Anti-Mouse/Human CD11b Antibody (M1/70) can alleviate renal fibrosis and inflammation. Anti-Mouse/Human CD11b Antibody (M1/70) can be used for research on inflammation conditions and cancer such as ischemia-reperfusion injury (IRI), thrombotic inflammatory conditions and ovarian cancer.

For research use only. We do not sell to patients.

Anti-Mouse/Human CD11b Antibody (M1/70) Chemical Structure

Anti-Mouse/Human CD11b Antibody (M1/70) Chemical Structure

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Anti-Mouse/Human CD11b Antibody (M1/70) is an anti-mouse CD11b IgG2b monoclonal antibody. Anti-Mouse/Human CD11b Antibody (M1/70) can significantly inhibit the adhesion between dendritic cells (DCs) and platelets. Anti-Mouse/Human CD11b Antibody (M1/70) can kill ovarian cancer cells and inhibit their migration. Anti-Mouse/Human CD11b Antibody (M1/70) can alleviate renal fibrosis and inflammation. Anti-Mouse/Human CD11b Antibody (M1/70) can be used for research on inflammation conditions and cancer such as ischemia-reperfusion injury (IRI), thrombotic inflammatory conditions and ovarian cancer[1][2][3].

In Vitro

Anti-Mouse/Human CD11b Antibody (M1/70) (10 μg/mL, 30 min) significantly inhibits the adhesion of bone marrow-derived dendritic cells (bmDCs) to fixed platelets[2].
Anti-Mouse/Human CD11b Antibody (M1/70) (5-10 μg/mL, 24 h) significantly kills epithelial ovarian cancer (EOC) cells[3].
Anti-Mouse/Human CD11b Antibody (M1/70) (5-15 μg/mL, 36 h) dose dependently inhibits cell migration in SKOV-3 and MDAH-2774 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Human CD11b Antibody (M1/70) Related Antibodies

Cell Viability Assay[3]

Cell Line: A2780, MDAH-2774, SKOV-3, OV90, TOV-21G, TOV112D and OV433 cells
Concentration: 5 and 10 μg/mL
Incubation Time: 24 h
Result: Significantly killed EOC cells with various efficacies ranging from 27 % to 96 %.

Cell Migration Assay [3]

Cell Line: SKOV-3 and MDAH-2774 cells
Concentration: 5, 10 and 15 μg/mL
Incubation Time: 36 h
Result: Delayed closure until 28 hours at 10 μg/mL, inhibited 50 % migration at 15 μg/mL.
In Vivo

Anti-Mouse/Human CD11b Antibody (M1/70) (2.5 mg/kg, i.p., once every 2 days, for 14 days) significantly reduces renal fibrosis and inflammation in male C57BL/6J mice with an ischemia­reperfusion injury (IRI) model[1].
Anti-Mouse/Human CD11b Antibody (M1/70) (50 μg, i.v., single dose) significantly inhibits the adhesion of DCs to damaged blood vessels in wild type C57BL/6 mice with a carotid artery ligation model[2].
Anti-Mouse/Human CD11b Antibody (M1/70) (60 μg, intratumoral injection, once daily, for 5 days) significantly inhibits tumor growth in female anthymic Nude-Foxn1nu mice bearing SKOV-3 tumors[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks) with an IRI model[1]
Dosage: 2.5 mg/kg
Administration: Intraperitoneal injection (i.p.), once every 2 days for 14 days
Result: Improved renal fibrosis.
Reduced the the level of Col1a1, Fn1, α-SMA and Col3a1.
Improved the pathological progression of severe acute kidney injury (AKI) to chronic kidney disease (CKD).
Animal Model: Wild type C57BL/6 mice with a carotid artery ligation model[2]
Dosage: 50 μg
Administration: Intravenous injection (i.v.), single dose
Result: Significantly inhibited the adhesion of DCs to damaged blood vessels.
Animal Model: 1.5×106 SKOV-3 cells injected female anthymic Nude-Foxn1nu mice[3]
Dosage: 60 μg
Administration: Intratumoral injection, once daily for 5 days
Result: Reduced tumor volume by 47 % on day 2, reduced tumor volume by 64.9 % on day 4 and reduced tumor volume by 59.7 % on day 5.
Had no significant systemic toxicity.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Human CD11b Antibody (M1/70)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse/Human CD11b Antibody (M1/70) Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human CD11b Antibody (M1/70)IntegrinCD11bplateletsDCIRIinflammationSKOV-3EOCInhibitorinhibitorinhibit

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