Anti-Mouse CD103 Antibody (M290)

Cat. No.: HY-P990295: Data Sheet
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Anti-Mouse CD103 Antibody (M290) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD103. Anti-Mouse CD103 Antibody (M290) can neutralize CD103. Anti-Mouse CD103 Antibody (M290) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as B16.gp33 tumor, colitis and diabetes.

For research use only. We do not sell to patients.

Anti-Mouse CD103 Antibody (M290) Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD103

In Vitro

Anti-Mouse CD103 Antibody (M290) (M290-MC-MMAF, N290 conjugated with Maleimidocaproyl-monomethyl auristatin F) (0-10 μg/mL, 48 h) reduces and inhibits the proliferation of CD8⁺ T cells in splenic lymphocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse CD103 Antibody (M290) (250 μg, i.p., every fifth day starting 1 day before adoptive transfer of either VHL-KO T cells) results in effective blockade of CD103 expression on VHL-KO TILs, which translated into loss of tumor control in B16.gp33 tumor mice^[1].
Anti-Mouse CD103 Antibody (M290) (1 mg at 1 day after T cell reconstitution and 0.5 mg twice a week for 8 weeks, i.p.) abrogates suppression of colitis by CD4⁺CD45RB^low T cells in colitis mice models^[2].
Anti-Mouse CD103 Antibody (M290) (M290-MC-MMAF, M290 conjugated with Maleimidocaproyl-monomethyl auristatin F) (3 mg/kg, i.p., at days 1, 3 and 5) promotes pancreatic islet allograft survival in diabetic C57BL/6 mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c islet allografts were transplanted into diabetic C57BL/6 mice^[3]
Dosage:	3 mg/kg (M290-MC-MMAF, N290 conjugated with Maleimidocaproyl-monomethyl auristatin F)
Administration:	Intraperitoneally injection, at days 1, 3 and 5
Result:	Prolonged islet allograft survival (>60 days). Revealed that fewer immune cells infiltrated the islet allografts. Showed more residual islets and an insulin-positive mass in the grafts. Prevented leukocyte infiltration and increased insulin secretion. Eliminated the CD8⁺CD103⁺ T-cell subpopulation. Reduced the levels of IL-4, IL-6, and TNF-α.

Gene ID

16407 [NCBI]

Accession

Q60677

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse CD103 Antibody (M290)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Liikanen I, et al. Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells. J Clin Invest. 2021 Apr 1;131(7):e143729. [Content Brief]

[2]. Annacker O, et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med. 2005 Oct 17;202(8):1051-61. [Content Brief]

[3]. Xue D, et al. An anti-CD103 antibody-drug conjugate prolongs the survival of pancreatic islet allografts in mice. Cell Death Dis. 2019 Sep 30;10(10):735. [Content Brief]

Anti-Mouse CD103 Antibody (M290) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD103 Antibody (M290)IntegrinCD103T cellsIsletB16.gp33ColitisDiabetesInhibitorinhibitorinhibit

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