2. PROTAC Anti-infection
  3. PROTACs SARS-CoV
  4. PROTAC SARS-CoV-2 Degrader-1

PROTAC SARS-CoV-2 Degrader-1 (Compound LLP019) is a PROTAC degrader targeting the SARS-CoV-2 main protease (MPro) with a DC50 value of 4.7 μM. PROTAC SARS-CoV-2 Degrader-1 induces MPro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Degrader-1 is promising for research of COVID-19 and related coronavirus infections. (Pink: DH03 (HY-32717); Black: linker (HY-42149); Blue: Thalidomide-4-O-CH2-COO(t-Bu) (HY-42771).

For research use only. We do not sell to patients.

PROTAC SARS-CoV-2 Degrader-1 Chemical Structure

PROTAC SARS-CoV-2 Degrader-1 Chemical Structure

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PROTAC SARS-CoV-2 Degrader-1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC SARS-CoV-2 Degrader-1 (Compound LLP019) is a PROTAC degrader targeting the SARS-CoV-2 main protease (MPro) with a DC50 value of 4.7 μM. PROTAC SARS-CoV-2 Degrader-1 induces MPro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Degrader-1 is promising for research of COVID-19 and related coronavirus infections. (Pink: DH03 (HY-32717); Black: linker (HY-42149); Blue: Thalidomide-4-O-CH2-COO(t-Bu) (HY-42771)[1].

Molecular Weight

830.21

Formula

C40H37ClFN7O10
SMILES

CCOC1=C(NC(CCOCCOCCNC(COC2=C(C(N(C3CCC(NC3=O)=O)C4=O)=O)C4=CC=C2)=O)=O)C=C(C(NC5=CC(Cl)=C(F)C=C5)=C(C#N)C=N6)C6=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SARS-CoV-2 Degrader-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SARS-CoV-2 Degrader-1PROTACsSARS-CoVSARS coronavirusPROTACMProSARS-CoV-2Inhibitorinhibitorinhibit

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