2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. Anaplastic lymphoma kinase (ALK) Fat Mass and Obesity-associated Protein (FTO)
  4. Ena15

Ena15 is an ALKBH5 inhibitor. Ena15 enhances the demethylase activity of FTO. Ena15 increases m6A RNA level, and stabilizes FOXM1 mRNA. Ena15 suppresses the growth activity of glioblastoma multiforme.

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Ena15

Ena15 Chemical Structure

CAS No. : 956935-02-7

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Based on 1 publication(s) in Google Scholar

Ena15 Related Antibodies

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Description

Ena15 is an ALKBH5 inhibitor. Ena15 enhances the demethylase activity of FTO. Ena15 increases m6A RNA level, and stabilizes FOXM1 mRNA. Ena15 suppresses the growth activity of glioblastoma multiforme[1].

Molecular Weight

438.56

Formula

C28H30N4O
CAS No.
Appearance

Viscous Liquid

Color

Yellow to orange

SMILES

O=C(N(CC1=CC=C(CC)C=C1)CC2=CC=CN=C2)C3=C(C)N(CC4=CC=CC=C4)N=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (142.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2802 mL 11.4009 mL 22.8019 mL
5 mM 0.4560 mL 2.2802 mL 4.5604 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (252 KB)

COA (256 KB) LCMS (84 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2802 mL 11.4009 mL 22.8019 mL 57.0047 mL
5 mM 0.4560 mL 2.2802 mL 4.5604 mL 11.4009 mL
10 mM 0.2280 mL 1.1401 mL 2.2802 mL 5.7005 mL
15 mM 0.1520 mL 0.7601 mL 1.5201 mL 3.8003 mL
20 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
25 mM 0.0912 mL 0.4560 mL 0.9121 mL 2.2802 mL
30 mM 0.0760 mL 0.3800 mL 0.7601 mL 1.9002 mL
40 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4251 mL
50 mM 0.0456 mL 0.2280 mL 0.4560 mL 1.1401 mL
60 mM 0.0380 mL 0.1900 mL 0.3800 mL 0.9501 mL
80 mM 0.0285 mL 0.1425 mL 0.2850 mL 0.7126 mL
100 mM 0.0228 mL 0.1140 mL 0.2280 mL 0.5700 mL
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Ena15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ena15956935-02-7Ena 15Ena-15Anaplastic lymphoma kinase (ALK)Fat Mass and Obesity-associated Protein (FTO)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246glioblastoma multiformecell proliferationantitumorInhibitorinhibitorinhibit

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