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  3. c-Fms
  4. Anti-Mouse CSF1R/CD115 Antibody (AFS98)

Anti-Mouse CSF1R/CD115 Antibody (AFS98) 

Cat. No.: HY-P990125 Purity: 99.38%
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Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1R IgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis.

For research use only. We do not sell to patients.

Anti-Mouse CSF1R/CD115 Antibody (AFS98)

Anti-Mouse CSF1R/CD115 Antibody (AFS98) Chemical Structure

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Description

Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1R IgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis[1][2][3][4].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

CSF1R/CD115
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CSF1R/CD115 Antibody (AFS98) Related Antibodies
In Vivo

Anti-Mouse (CSF1R/CD115) Antibody (AFS98) (directly injecyion, 48 h before MCAo) depletes microglia in aged animals but results in increased neuroinflammation after ischemic stroke[1].
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) (25 mg/kg, i.p., every second day for 6 weeks) suppresses the progression of established diabetic nephropathy[2].
in Obese (db/db) mice by targeting macrophage-mediated injury[2].
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) (2 mg/mouse, i.p., every second day for 6 weeks) acts as protection from early atherogenesis in apoE-deficient mice[3].
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) (25 or 50 mg/kg, i.p., every day for 14 days) shows significant antiinflammatory effects in Collagen-induced arthritis (CIA) mice models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Obese (db/db) mice models (C57BL/KS, 12 weeks)[2]
Dosage: 25 mg/kg
Administration: Intraperitoneal injections, every second day for 6 weeks
Result: Reduced renal hypertrophy, but not obesity, diabetes or circulating monocytes.
Reduced macrophage accumulation in diabetic kidneys.
Suppressed diabetic glomerular hyperfiltration without altering albuminuria.
Reduced ubular damage and tubulo-interstitial fibrosis.
Upregulated the levels of phospho-ERK, phospho-p38, phospho-JNK, phospho-ATF2 and α-tubulin.
Animal Model: ApoE-deficient mice fed a high-fat diet from 6 to 12 weeks of age[3]
Dosage: 2 mg/mouse
Administration: Intraperitoneal injections, every second day for 6 weeks
Result: Prevented development of fatty streaks.
Suppressed the accumulation of macrophage-derived foam cells in the aortic root by 70%.
Animal Model: Collagen-induced arthritis (CIA) mice models (DBA/1, male, 7-9 weeks)[4]
Dosage: 25 or 50 mg/kg
Administration: Intraperitoneal injections, every day for 14 days
Result: Inhibitd inflammatory bone and cartilage loss.
Reduced synovial joint macrophage infiltrates and splenic monocyte recruitment.
Blocked systemic bone loss by blockade of osteoclast differentiation.
Protected against bone and cartilage erosion independent of effects on inflammation in serum-transfer arthritis.
Gene ID

12978  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CSF1R/CD115 Antibody (AFS98)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.38%

SDS (251 KB)

COA (232 KB) SDS-PAGE (64 KB) SEC-HPLC (167 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse CSF1R/CD115 Antibody (AFS98) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CSF1R/CD115 Antibody (AFS98)c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RCD115StoreDiabetesCIAInhibitorinhibitorinhibit

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